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A genome-wide association study of aging.

TitleA genome-wide association study of aging.
Publication TypeJournal Article
Year of Publication2011
AuthorsWalter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, Lunetta KL, Milaneschi Y, Tanaka T, Tranah GJ, Völker U, Yu L, Arnold A, Benjamin EJ, Biffar R, Buchman AS, Boerwinkle E, Couper DJ, De Jager PL, Evans DA, Harris TB, Hoffmann W, Hofman A, Karasik D, Kiel DP, Kocher T, Kuningas M, Launer LJ, Lohman KK, Lutsey PL, Mackenbach J, Marciante K, Psaty BM, Reiman EM, Rotter JI, Seshadri S, Shardell MD, Smith AV, van Duijn C, Walston J, Zillikens CM, Bandinelli S, Baumeister SE, Bennett DA, Ferrucci L, Gudnason V, Kivimaki M, Liu Y, Murabito JM, Newman AB, Tiemeier H
Secondary AuthorsFranceschini N
JournalNeurobiol Aging
Volume32
Issue11
Pagination2109.e15-28
Date Published2011 Nov
ISSN1558-1497
KeywordsAging, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Longevity
Abstract

Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death. No single nucleotide polymorphism (SNP) was a genome-wide significant predictor of either outcome (p

DOI10.1016/j.neurobiolaging.2011.05.026
Alternate JournalNeurobiol Aging
PubMed ID21782286
PubMed Central IDPMC3193030
Grant ListN01HC55018 / HL / NHLBI NIH HHS / United States
U19 AG023122 / AG / NIA NIH HHS / United States
263 MD 821336 / MD / NIMHD NIH HHS / United States
R01 AG032098 / AG / NIA NIH HHS / United States
M01 RR000425 / RR / NCRR NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
P30 AG019610 / AG / NIA NIH HHS / United States
RG/07/008/23674 / / British Heart Foundation / United Kingdom
N01HC55020 / HL / NHLBI NIH HHS / United States
1R03AG032498-01 / AG / NIA NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
M01 RR00425 / RR / NCRR NIH HHS / United States
UL1 TR000005 / TR / NCATS NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
N01AG12100 / AG / NIA NIH HHS / United States
R01 HL036310 / HL / NHLBI NIH HHS / United States
N01-HC-85085 / HC / NHLBI NIH HHS / United States
G19/35 / / Medical Research Council / United Kingdom
N01 AG062101 / AG / NIA NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-85081 / HC / NHLBI NIH HHS / United States
G0100222 / / Medical Research Council / United Kingdom
R01 MD009164 / MD / NIMHD NIH HHS / United States
R01 AG030146 / AG / NIA NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01 HC015103 / HC / NHLBI NIH HHS / United States
1R01-AG028321 / AG / NIA NIH HHS / United States
P30 AG013846 / AG / NIA NIH HHS / United States
G8802774 / / Medical Research Council / United Kingdom
R01 AG017917 / AG / NIA NIH HHS / United States
AG033193 / AG / NIA NIH HHS / United States
1R01AG032098-01A1 / AG / NIA NIH HHS / United States
G0902037 / / Medical Research Council / United Kingdom
R01 HL087652 / HL / NHLBI NIH HHS / United States
R01 AR/AG 41398 / AG / NIA NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
N01 AG062106 / AG / NIA NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-85086 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
NS17950 / NS / NINDS NIH HHS / United States
R01 AR041398 / AR / NIAMS NIH HHS / United States
R37 AG013196 / AG / NIA NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
HHSN268200782096C / HG / NHGRI NIH HHS / United States
R01 AG008122 / AG / NIA NIH HHS / United States
N01 HC-55222 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
P30AG013846 / AG / NIA NIH HHS / United States
N01 AG062103 / AG / NIA NIH HHS / United States
R01 AG029451 / AG / NIA NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
N01-HC-75150 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R03 AG032498 / AG / NIA NIH HHS / United States
/ ImNIH / Intramural NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
AG081220 / AG / NIA NIH HHS / United States
R01 AG013196 / AG / NIA NIH HHS / United States
R01AG029451 / AG / NIA NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
N01HC85079 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 AG028321 / AG / NIA NIH HHS / United States
263 MD 9164 / MD / NIMHD NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
R01 AG031890 / AG / NIA NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
N01-HC-85084 / HC / NHLBI NIH HHS / United States
R01 AG015819 / AG / NIA NIH HHS / United States