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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

TitleParent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Publication TypeJournal Article
Year of Publication2014
AuthorsPerry JRb, Day F, Elks CE, et al.
Secondary AuthorsOng KK
Corporate AuthorsAustralian Ovarian Cancer Study, GENICA Network, kConFab, LifeLines Cohort Study, InterAct Consortium, Early Growth Genetics(EGG) Consortium
JournalNature
Volume514
Issue7520
Pagination92-97
Date Published2014 Oct 02
ISSN1476-4687
KeywordsAdolescent, Age Factors, Alleles, Body Mass Index, Breast Neoplasms, Calcium-Binding Proteins, Cardiovascular Diseases, Child, Diabetes Mellitus, Type 2, Europe, Female, Genetic Loci, Genome-Wide Association Study, Genomic Imprinting, Humans, Hypothalamo-Hypophyseal System, Intercellular Signaling Peptides and Proteins, Male, Membrane Proteins, Menarche, Obesity, Ovary, Parents, Polymorphism, Single Nucleotide, Potassium Channels, Tandem Pore Domain, Proteins, Quantitative Trait Loci, Receptors, GABA-B, Receptors, Retinoic Acid, Ribonucleoproteins
Abstract

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P 

DOI10.1038/nature13545
Alternate JournalNature
PubMed ID25231870
PubMed Central IDPMC4185210
Grant ListR01 NS017950 / NS / NINDS NIH HHS / United States
MC_UU_12013/3 / MRC_ / Medical Research Council / United Kingdom
11022 / CRUK_ / Cancer Research UK / United Kingdom
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
MC_U106179471 / MRC_ / Medical Research Council / United Kingdom
MC_U106179472 / MRC_ / Medical Research Council / United Kingdom
098381 / WT_ / Wellcome Trust / United Kingdom
10118 / CRUK_ / Cancer Research UK / United Kingdom
G1000143 / MRC_ / Medical Research Council / United Kingdom
MR/J012165/1 / MRC_ / Medical Research Council / United Kingdom
R01 AG041517 / AG / NIA NIH HHS / United States
UL1 TR001108 / TR / NCATS NIH HHS / United States
102215 / WT_ / Wellcome Trust / United Kingdom
MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom
MC_PC_15018 / MRC_ / Medical Research Council / United Kingdom
P50 CA116201 / CA / NCI NIH HHS / United States
G0401527 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12013/1 / MRC_ / Medical Research Council / United Kingdom
G0701863 / MRC_ / Medical Research Council / United Kingdom
G9815508 / MRC_ / Medical Research Council / United Kingdom
10124 / CRUK_ / Cancer Research UK / United Kingdom
U01 AG049505 / AG / NIA NIH HHS / United States