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Serum uric acid, gout, and venous thromboembolism: The atherosclerosis risk in communities study.

TitleSerum uric acid, gout, and venous thromboembolism: The atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2016
AuthorsKubota Y, McAdams-DeMarco M
Secondary AuthorsFolsom AR
JournalThromb Res
Volume144
Pagination144-8
Date Published2016 Aug
ISSN1879-2472
KeywordsAtherosclerosis, Biomarkers, Female, Gout, Humans, Middle Aged, Prospective Studies, Risk Factors, Uric Acid, Venous Thromboembolism
Abstract

INTRODUCTION: Inflammatory diseases increase risk of venous thromboembolism (VTE). Whether gout, the most common rheumatologic inflammatory arthritis, or its cause, elevated serum uric acid (SUA), is associated with VTE incidence is unknown.

MATERIALS AND METHODS: The Atherosclerosis Risk in Communities Study measured SUA in 14126 participants aged 45-64, without a history of VTE or gout and not using anticoagulants/gout medications, and obtained information on incident gout between 1987 and 1998 from 10247. We followed them for VTE occurrence from 1987 to 2011. Hazard ratios (HRs) of VTE were estimated using Cox proportional hazards models.

RESULTS: We documented 632 incident cases of VTE (236 unprovoked and 396 provoked). Age, sex, and race-adjusted HRs for total VTE were 1, 1.40, 1.43, 1.91, 1.71, and 3.25 (P for trend

CONCLUSIONS: Elevated SUA was associated with an increased risk of VTE, suggesting that SUA might be a novel risk factor or marker for VTE. Further studies are needed to assess the association between gout and VTE.

DOI10.1016/j.thromres.2016.06.020
Alternate JournalThromb Res
PubMed ID27337701
PubMed Central IDPMC5120547
Grant ListHHSN268201100008C / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States