Title | Meta-analysis of epigenome-wide association studies of cognitive abilities. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai P-C, Vojinovic D, Simino J, Levy D, Liu C, Mendelson M, Satizabal CL, Yang Q, Jhun MA, Kardia SLR, Zhao W, Bandinelli S, Ferrucci L, Hernandez DG, Singleton AB, Harris SE, Starr JM, Kiel DP, McLean RR, Just AC, Schwartz J, Spiro A, Vokonas P, Amin N, M Ikram A, Uitterlinden AG, van Meurs JBJ, Spector TD, Steves C, Baccarelli AA, Bell JT, van Duijn CM, Fornage M, Hsu Y-H, Mill J, Mosley TH, Seshadri S |
Secondary Authors | Deary IJ |
Journal | Mol Psychiatry |
Volume | 23 |
Issue | 11 |
Pagination | 2133-2144 |
Date Published | 2018 11 |
ISSN | 1476-5578 |
Keywords | Adult, Aged, Aged, 80 and over, Cognition, Cohort Studies, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Genome-Wide Association Study, Genomics, Humans, Male, Middle Aged |
Abstract | Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable. Epigenetic modifications, such as DNA methylation, are susceptible to both genetic and environmental factors and may provide insights into individual differences in cognitive functions. Epigenome-wide meta-analyses for blood-based DNA methylation levels at ~420,000 CpG sites were performed for seven measures of cognitive functioning using data from 11 cohorts. CpGs that passed a Bonferroni correction, adjusting for the number of CpGs and cognitive tests, were assessed for: longitudinal change; being under genetic control (methylation QTLs); and associations with brain health (structural MRI), brain methylation and Alzheimer's disease pathology. Across the seven measures of cognitive functioning (meta-analysis n range: 2557-6809), there were epigenome-wide significant (P  |
DOI | 10.1038/s41380-017-0008-y |
Alternate Journal | Mol Psychiatry |
PubMed ID | 29311653 |
PubMed Central ID | PMC6035894 |
Grant List | CZB/4/505 / CSO_ / Chief Scientist Office / United Kingdom R01 AG054076 / AG / NIA NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States R01 NS087541 / NS / NINDS NIH HHS / United States Z99 AG999999 / ImNIH / Intramural NIH HHS / United States MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom P30 ES023515 / ES / NIEHS NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States Z01 AG000949-02 / ImNIH / Intramural NIH HHS / United States BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom R21 AR056405 / AR / NIAMS NIH HHS / United States U01 AG049505 / AG / NIA NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States R01 NS017950 / NS / NINDS NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States MR/M013111/1 / MRC_ / Medical Research Council / United Kingdom G1001245 / MRC_ / Medical Research Council / United Kingdom Z01 AG000932-01 / ImNIH / Intramural NIH HHS / United States G0701120 / MRC_ / Medical Research Council / United Kingdom U01 AG052409 / AG / NIA NIH HHS / United States R01 HL133221 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States R00 ES023450 / ES / NIEHS NIH HHS / United States K99 HL136875 / HL / NHLBI NIH HHS / United States |