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Meta-analysis of epigenome-wide association studies of cognitive abilities.

TitleMeta-analysis of epigenome-wide association studies of cognitive abilities.
Publication TypeJournal Article
Year of Publication2018
AuthorsMarioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai P-C, Vojinovic D, Simino J, Levy D, Liu C, Mendelson M, Satizabal CL, Yang Q, Jhun MA, Kardia SLR, Zhao W, Bandinelli S, Ferrucci L, Hernandez DG, Singleton AB, Harris SE, Starr JM, Kiel DP, McLean RR, Just AC, Schwartz J, Spiro A, Vokonas P, Amin N, M Ikram A, Uitterlinden AG, van Meurs JBJ, Spector TD, Steves C, Baccarelli AA, Bell JT, van Duijn CM, Fornage M, Hsu Y-H, Mill J, Mosley TH, Seshadri S
Secondary AuthorsDeary IJ
JournalMol Psychiatry
Volume23
Issue11
Pagination2133-2144
Date Published2018 11
ISSN1476-5578
KeywordsAdult, Aged, Aged, 80 and over, Cognition, Cohort Studies, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Genome-Wide Association Study, Genomics, Humans, Male, Middle Aged
Abstract

Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable. Epigenetic modifications, such as DNA methylation, are susceptible to both genetic and environmental factors and may provide insights into individual differences in cognitive functions. Epigenome-wide meta-analyses for blood-based DNA methylation levels at ~420,000 CpG sites were performed for seven measures of cognitive functioning using data from 11 cohorts. CpGs that passed a Bonferroni correction, adjusting for the number of CpGs and cognitive tests, were assessed for: longitudinal change; being under genetic control (methylation QTLs); and associations with brain health (structural MRI), brain methylation and Alzheimer's disease pathology. Across the seven measures of cognitive functioning (meta-analysis n range: 2557-6809), there were epigenome-wide significant (P 

DOI10.1038/s41380-017-0008-y
Alternate JournalMol Psychiatry
PubMed ID29311653
PubMed Central IDPMC6035894
Grant ListCZB/4/505 / CSO_ / Chief Scientist Office / United Kingdom
R01 AG054076 / AG / NIA NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
R01 NS087541 / NS / NINDS NIH HHS / United States
Z99 AG999999 / ImNIH / Intramural NIH HHS / United States
MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom
P30 ES023515 / ES / NIEHS NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
Z01 AG000949-02 / ImNIH / Intramural NIH HHS / United States
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
R21 AR056405 / AR / NIAMS NIH HHS / United States
U01 AG049505 / AG / NIA NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
MR/M013111/1 / MRC_ / Medical Research Council / United Kingdom
G1001245 / MRC_ / Medical Research Council / United Kingdom
Z01 AG000932-01 / ImNIH / Intramural NIH HHS / United States
G0701120 / MRC_ / Medical Research Council / United Kingdom
U01 AG052409 / AG / NIA NIH HHS / United States
R01 HL133221 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States
R00 ES023450 / ES / NIEHS NIH HHS / United States
K99 HL136875 / HL / NHLBI NIH HHS / United States