| Title | Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | de Vries PS, Brown MR, Bentley AR, et al. |
| Secondary Authors | Morrison AC |
| Corporate Authors | InterAct Consortium, Lifelines Cohort, Groningen, The Netherlands(Lifelines Cohort Study) |
| Journal | Am J Epidemiol |
| Volume | 188 |
| Issue | 6 |
| Pagination | 1033-1054 |
| Date Published | 2019 06 01 |
| ISSN | 1476-6256 |
| Keywords | Adolescent, Adult, Aged, Alcohol Drinking, Cholesterol, HDL, Cholesterol, LDL, Continental Population Groups, Female, Genome-Wide Association Study, Genotype, Humans, Life Style, Lipids, Male, Middle Aged, Phenotype, Triglycerides, Vascular Endothelial Growth Factor B, Young Adult |
| Abstract | A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P |
| DOI | 10.1093/aje/kwz005 |
| Alternate Journal | Am J Epidemiol |
| PubMed ID | 30698716 |
| PubMed Central ID | PMC6545280 |
| Grant List | R01 DK093757 / DK / NIDDK NIH HHS / United States HHSN268201100012C / HL / NHLBI NIH HHS / United States MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom U10 HL054472 / HL / NHLBI NIH HHS / United States U01 HL054472 / HL / NHLBI NIH HHS / United States RC4 AG039029 / AG / NIA NIH HHS / United States R01 HL071025 / HL / NHLBI NIH HHS / United States U01 HL054471 / HL / NHLBI NIH HHS / United States R01 HL103612 / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States U01 HL054496 / HL / NHLBI NIH HHS / United States U10 HL054497 / HL / NHLBI NIH HHS / United States R01 HL053353 / HL / NHLBI NIH HHS / United States R01 DK085175 / DK / NIDDK NIH HHS / United States HHSN268201300005C / HL / NHLBI NIH HHS / United States HHSN268201100001I / HL / NHLBI NIH HHS / United States Z01 AG000513 / ImNIH / Intramural NIH HHS / United States ZIA HG000024 / ImNIH / Intramural NIH HHS / United States N01AG12100 / AG / NIA NIH HHS / United States HHSN268201300026C / HL / NHLBI NIH HHS / United States MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom R56 DK062370 / DK / NIDDK NIH HHS / United States N01HC95160 / HL / NHLBI NIH HHS / United States U01 HG004446 / HG / NHGRI NIH HHS / United States MR/K002414/1 / MRC_ / Medical Research Council / United Kingdom R01 HL120393 / HL / NHLBI NIH HHS / United States R01 HL087698 / HL / NHLBI NIH HHS / United States R01 HL071917 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States R03 AG046389 / AG / NIA NIH HHS / United States U10 HL054509 / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States BHF/RG/2000004 / BHF_ / British Heart Foundation / United Kingdom U01 AG009740 / AG / NIA NIH HHS / United States N01 AG062101 / AG / NIA NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States N01HC95163 / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201500001C / HL / NHLBI NIH HHS / United States SP/04/002 / BHF_ / British Heart Foundation / United Kingdom HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100004I / HL / NHLBI NIH HHS / United States Z01 HG200362 / ImNIH / Intramural NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States U01 HL130114 / HL / NHLBI NIH HHS / United States R01 HL087660 / HL / NHLBI NIH HHS / United States PG/02/128 / BHF_ / British Heart Foundation / United Kingdom R01 HL043851 / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States U10 HL054464 / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States G0700931 / MRC_ / Medical Research Council / United Kingdom U01 HL054497 / HL / NHLBI NIH HHS / United States R01 HL085251 / HL / NHLBI NIH HHS / United States U01 HL054509 / HL / NHLBI NIH HHS / United States N01HC95169 / HL 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