Title | The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Yu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CBarrios, Ben-Shlomo Y, Boerwinkle E, Casas JP, Clish C, Dale C, Dehghan A, Derkach A, A Eliassen H, Elliott P, Fahy E, Gieger C, Gunter MJ, Harada S, Harris T, Herr DR, Herrington D, Hirschhorn JN, Hoover E, Hsing AW, Johansson M, Kelly RS, Khoo CMeng, Kivimaki M, Kristal BS, Langenberg C, Lasky-Su J, Lawlor DA, Lotta LA, Mangino M, Le Marchand L, Mathé E, Matthews CE, Menni C, Mucci LA, Murphy R, Oresic M, Orwoll E, Ose J, Pereira AC, Playdon MC, Poston L, Price J, Qi Q, Rexrode K, Risch A, Sampson J, Seow WJie, Sesso HD, Shah SH, Shu X-O, Smith GCS, Sovio U, Stevens VL, Stolzenberg-Solomon R, Takebayashi T, Tillin T, Travis R, Tzoulaki I, Ulrich CM, Vasan RS, Verma M, Wang Y, Wareham NJ, Wong A, Younes N, Zhao H, Zheng W |
Secondary Authors | Moore SC |
Journal | Am J Epidemiol |
Volume | 188 |
Issue | 6 |
Pagination | 991-1012 |
Date Published | 2019 06 01 |
ISSN | 1476-6256 |
Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Body Mass Index, Child, Epidemiologic Methods, Epidemiology, Female, Global Health, Health Behavior, Hematologic Tests, Humans, Longitudinal Studies, Male, Metabolomics, Middle Aged, Prospective Studies, Socioeconomic Factors, Young Adult |
Abstract | The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, and South America that together include more than 136,000 participants with blood metabolomics data on samples collected from 1985 to 2017. Metabolomics data were provided by 17 different platforms, with the most frequently used labs being Metabolon, Inc. (14 cohorts), the Broad Institute (15 cohorts), and Nightingale Health (11 cohorts). Participants have been followed for a median of 23 years for health outcomes including death, cancer, cardiovascular disease, diabetes, and others; many of the studies are ongoing. Available exposure-related data include common clinical measurements and behavioral factors, as well as genome-wide genotype data. Two feasibility studies were conducted to evaluate the comparability of metabolomics platforms used by COMETS cohorts. The first study showed that the overlap between any 2 different laboratories ranged from 6 to 121 metabolites at 5 leading laboratories. The second study showed that the median Spearman correlation comparing 111 overlapping metabolites captured by Metabolon and the Broad Institute was 0.79 (interquartile range, 0.56-0.89). |
DOI | 10.1093/aje/kwz028 |
Alternate Journal | Am J Epidemiol |
PubMed ID | 31155658 |
PubMed Central ID | PMC6545286 |
Grant List | U01 DK048434 / DK / NIDDK NIH HHS / United States C570/A16491 / CRUK_ / Cancer Research UK / United Kingdom U01 DK048413 / DK / NIDDK NIH HHS / United States UL1 TR002369 / TR / NCATS NIH HHS / United States CZQ/1/38 / / Chief Scientist Office [UK] / International G1000143 / MRC_ / Medical Research Council / United Kingdom MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom M01 RR016587 / RR / NCRR NIH HHS / United States MR/L00002/1 / MRC_ / Medical Research Council / United Kingdom U01 DK048400 / DK / NIDDK NIH HHS / United States U01 DK048468 / DK / NIDDK NIH HHS / United States U01 DK048407 / DK / NIDDK NIH HHS / United States U01 DK048437 / DK / NIDDK NIH HHS / United States U01 DK048406 / DK / NIDDK NIH HHS / United States G1001357 / MRC_ / Medical Research Council / United Kingdom MC_UU_12019/1 / MRC_ / Medical Research Council / United Kingdom U01 DK048412 / DK / NIDDK NIH HHS / United States P30 DK040561 / DK / NIDDK NIH HHS / United States MR/R024227/1 / MRC_ / Medical Research Council / United Kingdom U01 DK048375 / DK / NIDDK NIH HHS / United States 206046/Z/17/Z / WT_ / Wellcome Trust / United Kingdom 14136 / CRUK_ / Cancer Research UK / United Kingdom CS/13/1/30327 / BHF_ / British Heart Foundation / United Kingdom WT092830/Z/10/ Z / WT_ / Wellcome Trust / United Kingdom RG/10/12/28456 / BHF_ / British Heart Foundation / United Kingdom R01 HL141826 / HL / NHLBI NIH HHS / United States MR/L01632X/1 / MRC_ / Medical Research Council / United Kingdom CS/16/4/32482 / BHF_ / British Heart Foundation / United Kingdom G1100221 / MRC_ / Medical Research Council / United Kingdom RP-PG-0407-10452 / DH_ / Department of Health / United Kingdom U01 DK048397 / DK / NIDDK NIH HHS / United States U01 DK048381 / DK / NIDDK NIH HHS / United States K01 HL129892 / HL / NHLBI NIH HHS / United States MC_PC_13046 / MRC_ / Medical Research Council / United Kingdom U01 DK048339 / DK / NIDDK NIH HHS / United States U01 DK048514 / DK / NIDDK NIH HHS / United States U01 DK048485 / DK / NIDDK NIH HHS / United States G0500877 / MRC_ / Medical Research Council / United Kingdom MR/M012190/1 / MRC_ / Medical Research Council / United Kingdom / / Department of Health [UK] / International U01 DK048443 / DK / NIDDK NIH HHS / United States MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom MR/S011676/1 / MRC_ / Medical Research Council / United Kingdom SP/07/001/23603 / BHF_ / British Heart Foundation / United Kingdom WT082464 / WT_ / Wellcome Trust / United Kingdom MR/L002477/1 / MRC_ / Medical Research Council / United Kingdom 1000143 / MRC_ / Medical Research Council / United Kingdom MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom MC_PC_13048 / MRC_ / Medical Research Council / United Kingdom K01 HL146980 / HL / NHLBI NIH HHS / United States 102215/2/13/2 / WT_ / Wellcome Trust / United Kingdom U01 DK048489 / DK / NIDDK NIH HHS / United States U01 DK048349 / DK / NIDDK NIH HHS / United States U01 DK048377 / DK / NIDDK NIH HHS / United States P30 DK017047 / DK / NIDDK NIH HHS / United States |