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The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

TitleThe Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.
Publication TypeJournal Article
Year of Publication2019
AuthorsYu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CBarrios, Ben-Shlomo Y, Boerwinkle E, Casas JP, Clish C, Dale C, Dehghan A, Derkach A, A Eliassen H, Elliott P, Fahy E, Gieger C, Gunter MJ, Harada S, Harris T, Herr DR, Herrington D, Hirschhorn JN, Hoover E, Hsing AW, Johansson M, Kelly RS, Khoo CMeng, Kivimaki M, Kristal BS, Langenberg C, Lasky-Su J, Lawlor DA, Lotta LA, Mangino M, Le Marchand L, Mathé E, Matthews CE, Menni C, Mucci LA, Murphy R, Oresic M, Orwoll E, Ose J, Pereira AC, Playdon MC, Poston L, Price J, Qi Q, Rexrode K, Risch A, Sampson J, Seow WJie, Sesso HD, Shah SH, Shu X-O, Smith GCS, Sovio U, Stevens VL, Stolzenberg-Solomon R, Takebayashi T, Tillin T, Travis R, Tzoulaki I, Ulrich CM, Vasan RS, Verma M, Wang Y, Wareham NJ, Wong A, Younes N, Zhao H, Zheng W
Secondary AuthorsMoore SC
JournalAm J Epidemiol
Volume188
Issue6
Pagination991-1012
Date Published2019 06 01
ISSN1476-6256
KeywordsAdolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Body Mass Index, Child, Epidemiologic Methods, Epidemiology, Female, Global Health, Health Behavior, Hematologic Tests, Humans, Longitudinal Studies, Male, Metabolomics, Middle Aged, Prospective Studies, Socioeconomic Factors, Young Adult
Abstract

The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, and South America that together include more than 136,000 participants with blood metabolomics data on samples collected from 1985 to 2017. Metabolomics data were provided by 17 different platforms, with the most frequently used labs being Metabolon, Inc. (14 cohorts), the Broad Institute (15 cohorts), and Nightingale Health (11 cohorts). Participants have been followed for a median of 23 years for health outcomes including death, cancer, cardiovascular disease, diabetes, and others; many of the studies are ongoing. Available exposure-related data include common clinical measurements and behavioral factors, as well as genome-wide genotype data. Two feasibility studies were conducted to evaluate the comparability of metabolomics platforms used by COMETS cohorts. The first study showed that the overlap between any 2 different laboratories ranged from 6 to 121 metabolites at 5 leading laboratories. The second study showed that the median Spearman correlation comparing 111 overlapping metabolites captured by Metabolon and the Broad Institute was 0.79 (interquartile range, 0.56-0.89).

DOI10.1093/aje/kwz028
Alternate JournalAm J Epidemiol
PubMed ID31155658
PubMed Central IDPMC6545286
Grant ListU01 DK048434 / DK / NIDDK NIH HHS / United States
C570/A16491 / CRUK_ / Cancer Research UK / United Kingdom
U01 DK048413 / DK / NIDDK NIH HHS / United States
UL1 TR002369 / TR / NCATS NIH HHS / United States
CZQ/1/38 / / Chief Scientist Office [UK] / International
G1000143 / MRC_ / Medical Research Council / United Kingdom
MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom
M01 RR016587 / RR / NCRR NIH HHS / United States
MR/L00002/1 / MRC_ / Medical Research Council / United Kingdom
U01 DK048400 / DK / NIDDK NIH HHS / United States
U01 DK048468 / DK / NIDDK NIH HHS / United States
U01 DK048407 / DK / NIDDK NIH HHS / United States
U01 DK048437 / DK / NIDDK NIH HHS / United States
U01 DK048406 / DK / NIDDK NIH HHS / United States
G1001357 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12019/1 / MRC_ / Medical Research Council / United Kingdom
U01 DK048412 / DK / NIDDK NIH HHS / United States
P30 DK040561 / DK / NIDDK NIH HHS / United States
MR/R024227/1 / MRC_ / Medical Research Council / United Kingdom
U01 DK048375 / DK / NIDDK NIH HHS / United States
206046/Z/17/Z / WT_ / Wellcome Trust / United Kingdom
14136 / CRUK_ / Cancer Research UK / United Kingdom
CS/13/1/30327 / BHF_ / British Heart Foundation / United Kingdom
WT092830/Z/10/ Z / WT_ / Wellcome Trust / United Kingdom
RG/10/12/28456 / BHF_ / British Heart Foundation / United Kingdom
R01 HL141826 / HL / NHLBI NIH HHS / United States
MR/L01632X/1 / MRC_ / Medical Research Council / United Kingdom
CS/16/4/32482 / BHF_ / British Heart Foundation / United Kingdom
G1100221 / MRC_ / Medical Research Council / United Kingdom
RP-PG-0407-10452 / DH_ / Department of Health / United Kingdom
U01 DK048397 / DK / NIDDK NIH HHS / United States
U01 DK048381 / DK / NIDDK NIH HHS / United States
K01 HL129892 / HL / NHLBI NIH HHS / United States
MC_PC_13046 / MRC_ / Medical Research Council / United Kingdom
U01 DK048339 / DK / NIDDK NIH HHS / United States
U01 DK048514 / DK / NIDDK NIH HHS / United States
U01 DK048485 / DK / NIDDK NIH HHS / United States
G0500877 / MRC_ / Medical Research Council / United Kingdom
MR/M012190/1 / MRC_ / Medical Research Council / United Kingdom
/ / Department of Health [UK] / International
U01 DK048443 / DK / NIDDK NIH HHS / United States
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
MR/S011676/1 / MRC_ / Medical Research Council / United Kingdom
SP/07/001/23603 / BHF_ / British Heart Foundation / United Kingdom
WT082464 / WT_ / Wellcome Trust / United Kingdom
MR/L002477/1 / MRC_ / Medical Research Council / United Kingdom
1000143 / MRC_ / Medical Research Council / United Kingdom
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_13048 / MRC_ / Medical Research Council / United Kingdom
K01 HL146980 / HL / NHLBI NIH HHS / United States
102215/2/13/2 / WT_ / Wellcome Trust / United Kingdom
U01 DK048489 / DK / NIDDK NIH HHS / United States
U01 DK048349 / DK / NIDDK NIH HHS / United States
U01 DK048377 / DK / NIDDK NIH HHS / United States
P30 DK017047 / DK / NIDDK NIH HHS / United States