|Title||Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K|
|Secondary Authors||Markus HS|
|Corporate Authors||MEGASTROKE project of the International Stroke Genetics Consortium|
|Date Published||2019 02 26|
|Keywords||Brain Ischemia, Calcium, Humans, Intracranial Embolism, Magnesium, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Stroke|
OBJECTIVE: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.
METHODS: Analyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).
RESULTS: In standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; = 1.3 × 10) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; = 1.6 × 10) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.
CONCLUSIONS: This study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype.
|PubMed Central ID||PMC6404465|
|Grant List||MC_UU_00002/7 / MRC_ / Medical Research Council / United Kingdom |
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom