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New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.

TitleNew alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
Publication TypeJournal Article
Year of Publication2019
AuthorsEvangelou E, Gao H, Chu C, Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki H, Koskeridis F, Yiorkas AM, Karaman I, Elliott J, Luo Q, Aeschbacher S, Bartz TM, Baumeister SE, Braund PS, Brown MR, Brody JA, Clarke T-K, Dimou N, Faul JD, Homuth G, Jackson AU, Kentistou KA, Joshi PK, Lemaitre RN, Lind PA, Lyytikäinen L-P, Mangino M, Milaneschi Y, Nelson CP, Nolte IM, Perälä M-M, Polasek O, Porteous D, Ratliff SM, Smith JA, Stancáková A, Teumer A, Tuominen S, Thériault S, Vangipurapu J, Whitfield JB, Wood A, Yao J, Yu B, Zhao W, Arking DE, Auvinen J, Liu C, Männikkö M, Risch L, Rotter JI, Snieder H, Veijola J, Blakemore AI, Boehnke M, Campbell H, Conen D, Eriksson JG, Grabe HJ, Guo X, van der Harst P, Hartman CA, Hayward C, Heath AC, Jarvelin M-R, Kähönen M, Kardia SLR, Kühne M, Kuusisto J, Laakso M, Lahti J, Lehtimäki T, McIntosh AM, Mohlke KL, Morrison AC, Martin NG, Oldehinkel AJ, Penninx BWJH, Psaty BM, Raitakari OT, Rudan I, Samani NJ, Scott LJ, Spector TD, Verweij N, Weir DR, Wilson JF, Levy D, Tzoulaki I, Bell JD, Matthews PM, Rothenfluh A, Desrivières S, Schumann G
Secondary AuthorsElliott P
JournalNat Hum Behav
Volume3
Issue9
Pagination950-961
Date Published2019 09
ISSN2397-3374
KeywordsAdult, Aged, Alcohol Drinking, Alcoholism, Brain, European Continental Ancestry Group, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Neuroimaging, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Schizophrenia
Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

DOI10.1038/s41562-019-0653-z
Alternate JournalNat Hum Behav
PubMed ID31358974
Grant ListMC_QA137853 / MRC_ / Medical Research Council / United Kingdom
MR/L01341X/1 / MRC_ / Medical Research Council / United Kingdom
MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom
R21 DA040439 / DA / NIDA NIH HHS / United States
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom
MR/R026505/1 / MRC_ / Medical Research Council / United Kingdom
R01 DK062370 / DK / NIDDK NIH HHS / United States
MR/R00465X/1 / MRC_ / Medical Research Council / United Kingdom
G0700704 / MRC_ / Medical Research Council / United Kingdom
R01 AA026818 / AA / NIAAA NIH HHS / United States