Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.

TitleLeukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2020
AuthorsGondalia R, Holliday KM, Baldassari A, Justice AE, Stewart JD, Liao D, Yanosky JD, Engel SM, Jordahl KM, Bhatti P, Horvath S, Assimes TL, Pankow JS, Demerath EW, Guan W, Fornage M, Bressler J, North KE, Conneely KN, Li Y, Hou L, Baccarelli AA
Secondary AuthorsWhitsel EA
JournalEnviron Health Perspect
Volume128
Issue1
Pagination17004
Date Published2020 01
ISSN1552-9924
KeywordsAdult, Air Pollutants, Air Pollution, Atherosclerosis, Cardiovascular Diseases, Environmental Exposure, Female, Humans, Leukocytes, Particulate Matter, Women's Health
Abstract

BACKGROUND: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence of PM-associated leukocytosis is inconsistent and largely based on small, cross-sectional, and/or unrepresentative study populations.

OBJECTIVES: Our objective was to estimate PM-leukocyte associations among U.S. women and men in the Women's Health Initiative and Atherosclerosis Risk in Communities study ().

METHODS: We based the PM-leukocyte estimations on up to four study visits per participant, at which peripheral blood leukocytes and geocoded address-specific concentrations of , , and in diameter (, , and , respectively) were available. We multiply imputed missing data using chained equations and estimated PM-leukocyte count associations over daily to yearly PM exposure averaging periods using center-specific, linear, mixed, longitudinal models weighted for attrition and adjusted for sociodemographic, behavioral, meteorological, and geographic covariates. In a subset of participants with available data (), we also estimated PM-leukocyte proportion associations in compositional data analyses.

RESULTS: We found a (95% confidence interval: , 33) higher leukocyte count, a 1.2% (0.6%, 1.8%) higher granulocyte proportion, and a (, ) lower T-cell proportion per increase in 1-month mean . However, shorter-duration exposures were inversely and only modestly associated with leukocyte count.

DISCUSSION: The -leukocyte estimates, albeit imprecise, suggest that among racially, ethnically, and environmentally diverse U.S. populations, sustained, ambient exposure to fine PM may induce subclinical, but epidemiologically important, inflammatory effects. https://doi.org/10.1289/EHP5360.

DOI10.1289/EHP5360
Alternate JournalEnviron Health Perspect
PubMed ID31903802
PubMed Central IDPMC7015624
Grant ListR01 ES017794 / ES / NIEHS NIH HHS / United States
R01 ES020836 / ES / NIEHS NIH HHS / United States
R25 CA094880 / CA / NCI NIH HHS / United States
T32 CA094880 / CA / NCI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
R01 NS087541 / NS / NINDS NIH HHS / United States
HHSN268201100046C / HL / NHLBI NIH HHS / United States
HHSN268201100001C / WH / WHI NIH HHS / United States
HHSN268201100002C / WH / WHI NIH HHS / United States
HHSN268201100003C / WH / WHI NIH HHS / United States
HHSN268201100004C / WH / WHI NIH HHS / United States
HHSN271201100004C / AG / NIA NIH HHS / United States
HHSN268201100046C / HL / NHLBI NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
T32 ES007018 / ES / NIEHS NIH HHS / United States
/ RA / ARRA NIH HHS / United States