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Joint Associations of Obesity and NT-proBNP With the Incidence of Atrial Fibrillation in the ARIC Study.

TitleJoint Associations of Obesity and NT-proBNP With the Incidence of Atrial Fibrillation in the ARIC Study.
Publication TypeJournal Article
Year of Publication2019
AuthorsAlmuwaqqat Z, O'Neal WT, Norby FL, Lutsey PL, Selvin E, Soliman EZ, Chen LYee
Secondary AuthorsAlonso A
JournalJ Am Heart Assoc
Volume8
Issue19
Paginatione013294
Date Published2019 10
ISSN2047-9980
KeywordsAtrial Fibrillation, Biomarkers, Body Mass Index, Female, Humans, Incidence, Male, Middle Aged, Natriuretic Peptide, Brain, Obesity, Peptide Fragments, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, United States, Up-Regulation
Abstract

Background Circulating NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, a well-known indicator of atrial wall stress and remodeling, inversely correlate with body mass index. Both are strongly predictive of atrial fibrillation (AF). Their potential interaction in relation to incident AF, however, has not been explored. Methods and Results In total, 9556 participants of the ARIC (Atherosclerosis Risk in Communities) study who had 2 measurements of NT-proBNP and no baseline AF or heart failure were followed from 1996 to 1998 through 2016 for the occurrence of incident AF. Participants were categorized as obese (body mass index ≥30) and nonobese (body mass index

DOI10.1161/JAHA.119.013294
Alternate JournalJ Am Heart Assoc
PubMed ID31564186
PubMed Central IDPMC6806039
Grant List16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States
UL1 TR002378 / TR / NCATS NIH HHS / United States
TL1 TR002382 / TR / NCATS NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States