| Title | Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DKyeom, Lee MKyeong, Latourelle JC, Li X, Morrow JD, Obeidat M'en, Wyss AB, Bakke P, Barr GR, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJin, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim J-J, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, H Boezen M, Wain LV, Tobin MD, Hobbs BD |
| Secondary Authors | Cho MH |
| Corporate Authors | SpiroMeta Consortium, International COPD Genetics Consortium |
| Journal | Nat Genet |
| Volume | 51 |
| Issue | 3 |
| Pagination | 494-505 |
| Date Published | 2019 03 |
| ISSN | 1546-1718 |
| Keywords | Adult, Aged, Asthma, Case-Control Studies, Female, Gene Expression, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lung, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Smoking |
| Abstract | Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P |
| DOI | 10.1038/s41588-018-0342-2 |
| Alternate Journal | Nat Genet |
| PubMed ID | 30804561 |
| PubMed Central ID | PMC6546635 |
| Grant List | MR/N024842/1 / MRC_ / Medical Research Council / United Kingdom G1000861 / MRC_ / Medical Research Council / United Kingdom MC_PC_12010 / MRC_ / Medical Research Council / United Kingdom R01 HL089856 / HL / NHLBI NIH HHS / United States MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom U01 HL089856 / HL / NHLBI NIH HHS / United States R01 HL135142 / HL / NHLBI NIH HHS / United States P01 HL105339 / HL / NHLBI NIH HHS / United States R01 HL137927 / HL / NHLBI NIH HHS / United States K08 HL136928 / HL / NHLBI NIH HHS / United States R01 HL097163 / HL / NHLBI NIH HHS / United States P01 HL132825 / HL / NHLBI NIH HHS / United States R01 HL084323 / HL / NHLBI NIH HHS / United States MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom R01 HL113264 / HL / NHLBI NIH HHS / United States MC_QA137853 / MRC_ / Medical Research Council / United Kingdom MR/N011317/1 / MRC_ / Medical Research Council / United Kingdom MR/S003762/1 / MRC_ / Medical Research Council / United Kingdom G0700704 / MRC_ / Medical Research Council / United Kingdom / WT_ / Wellcome Trust / United Kingdom R33 HL120770 / HL / NHLBI NIH HHS / United States MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom |