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Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

TitleGenetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
Publication TypeJournal Article
Year of Publication2019
AuthorsSakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DKyeom, Lee MKyeong, Latourelle JC, Li X, Morrow JD, Obeidat M'en, Wyss AB, Bakke P, Barr GR, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJin, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim J-J, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, H Boezen M, Wain LV, Tobin MD, Hobbs BD
Secondary AuthorsCho MH
Corporate AuthorsSpiroMeta Consortium, International COPD Genetics Consortium
JournalNat Genet
Volume51
Issue3
Pagination494-505
Date Published2019 03
ISSN1546-1718
KeywordsAdult, Aged, Asthma, Case-Control Studies, Female, Gene Expression, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lung, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive, Pulmonary Fibrosis, Smoking
Abstract

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P

DOI10.1038/s41588-018-0342-2
Alternate JournalNat Genet
PubMed ID30804561
PubMed Central IDPMC6546635
Grant ListMR/N024842/1 / MRC_ / Medical Research Council / United Kingdom
G1000861 / MRC_ / Medical Research Council / United Kingdom
MC_PC_12010 / MRC_ / Medical Research Council / United Kingdom
R01 HL089856 / HL / NHLBI NIH HHS / United States
MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom
U01 HL089856 / HL / NHLBI NIH HHS / United States
R01 HL135142 / HL / NHLBI NIH HHS / United States
P01 HL105339 / HL / NHLBI NIH HHS / United States
R01 HL137927 / HL / NHLBI NIH HHS / United States
K08 HL136928 / HL / NHLBI NIH HHS / United States
R01 HL097163 / HL / NHLBI NIH HHS / United States
P01 HL132825 / HL / NHLBI NIH HHS / United States
R01 HL084323 / HL / NHLBI NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
R01 HL113264 / HL / NHLBI NIH HHS / United States
MC_QA137853 / MRC_ / Medical Research Council / United Kingdom
MR/N011317/1 / MRC_ / Medical Research Council / United Kingdom
MR/S003762/1 / MRC_ / Medical Research Council / United Kingdom
G0700704 / MRC_ / Medical Research Council / United Kingdom
/ WT_ / Wellcome Trust / United Kingdom
R33 HL120770 / HL / NHLBI NIH HHS / United States
MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom