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Association of white matter microstructural integrity with cognition and dementia.

TitleAssociation of white matter microstructural integrity with cognition and dementia.
Publication TypeJournal Article
Year of Publication2019
AuthorsPower MC, Su D, Wu A, Reid RI, Jack CR, Knopman DS, Coresh JJ, Huang J, Kantarci K, Sharrett ARichey, Gottesman RG, Griswold ME
Secondary AuthorsMosley TH
JournalNeurobiol Aging
Date Published2019 11
KeywordsAged, Alzheimer Disease, Brain, Cognition, Cognitive Dysfunction, Cross-Sectional Studies, Dementia, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Female, Humans, Male, Middle Aged, White Matter

Late-life measures of white matter (WM) microstructural integrity may predict cognitive status, cognitive decline, and incident mild cognitive impairment (MCI) or dementia. We considered participants of the Atherosclerosis Risk in Communities study who underwent cognitive assessment and neuroimaging in 2011-2013 and were followed through 2016-2017 (n = 1775 for analyses of prevalent MCI and dementia, baseline cognitive performance, and longitudinal cognitive change and n = 889 for analyses of incident MCI, dementia, or death). Cross-sectionally, both overall WM fractional anisotropy and overall WM mean diffusivity were strongly associated with baseline cognitive performance and risk of prevalent MCI or dementia. Longitudinally, greater overall WM mean diffusivity was associated with accelerated cognitive decline, as well as incident MCI, incident dementia, and mortality, but WM fractional anisotropy was not robustly associated with cognitive change or incident cognitive impairment. Both cross-sectional and longitudinal associations were attenuated after additionally adjusting for likely downstream pathologic changes. Increased WM mean diffusivity may provide an early indication of dementia pathogenesis.

Alternate JournalNeurobiol Aging
PubMed ID31585368
PubMed Central IDPMC6914220
Grant ListHHSN268201700002I / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States