Title | Long-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Yano Y, Griswold M, Wang W, Greenland P, Lloyd-Jones DM, Heiss G, Gottesman RF |
Secondary Authors | Mosley TH |
Journal | J Am Heart Assoc |
Volume | 7 |
Issue | 15 |
Pagination | e009578 |
Date Published | 2018 08 07 |
ISSN | 2047-9980 |
Keywords | African Americans, Blood Pressure, Cognition, Cognitive Dysfunction, European Continental Ancestry Group, Female, Humans, Hypertension, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Systole |
Abstract | Background To understand how blood pressure ( BP ) from midlife and beyond is related to cognition in older age, a lifespan approach is needed. We assessed the associations of BP levels and variability from midlife on with subsequent cognitive change. Methods and Results The ARIC (Atherosclerosis Risk in Communities) Study participants underwent 4 clinic BP measurements (visit 1, 2, 3, and 4 BP s) between 1987 and 1998, and their mean levels and average real variability ( ARV ) were assessed as exposures. A global cognitive z score, estimated from the Delayed Word Recall Test, Digit Symbol Substitution Test, and Word Fluency Test scores, was calculated at 1996 to 1998 (visit 4) and 2011 to 2013 (visit 5). Among 11 408 participants (mean age, 54 years; 56% women; 21% black race), mean systolic BP ( SBP )/diastolic BP ( DBP ) level was 123/72 mm Hg, and ARV / ARV was 11/7 mm Hg. With linear mixed models, 1- SD increases of ARV (standardized regression coefficient [95% confidence interval], -0.03 [-0.04 to -0.01] points) and ARV (standardized regression coefficient [95% confidence interval], -0.02 [-0.03 to -0.002] points; both P |
DOI | 10.1161/JAHA.118.009578 |
Alternate Journal | J Am Heart Assoc |
PubMed ID | 30371241 |
PubMed Central ID | PMC6201456 |
Grant List | U01 HL096812 / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States K24 AG052573 / AG / NIA NIH HHS / United States |