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Long-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study.

TitleLong-Term Blood Pressure Level and Variability From Midlife to Later Life and Subsequent Cognitive Change: The ARIC Neurocognitive Study.
Publication TypeJournal Article
Year of Publication2018
AuthorsYano Y, Griswold M, Wang W, Greenland P, Lloyd-Jones DM, Heiss G, Gottesman RF
Secondary AuthorsMosley TH
JournalJ Am Heart Assoc
Volume7
Issue15
Paginatione009578
Date Published2018 08 07
ISSN2047-9980
KeywordsAfrican Americans, Blood Pressure, Cognition, Cognitive Dysfunction, European Continental Ancestry Group, Female, Humans, Hypertension, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Systole
Abstract

Background To understand how blood pressure ( BP ) from midlife and beyond is related to cognition in older age, a lifespan approach is needed. We assessed the associations of BP levels and variability from midlife on with subsequent cognitive change. Methods and Results The ARIC (Atherosclerosis Risk in Communities) Study participants underwent 4 clinic BP measurements (visit 1, 2, 3, and 4 BP s) between 1987 and 1998, and their mean levels and average real variability ( ARV ) were assessed as exposures. A global cognitive z score, estimated from the Delayed Word Recall Test, Digit Symbol Substitution Test, and Word Fluency Test scores, was calculated at 1996 to 1998 (visit 4) and 2011 to 2013 (visit 5). Among 11 408 participants (mean age, 54 years; 56% women; 21% black race), mean systolic BP ( SBP )/diastolic BP ( DBP ) level was 123/72 mm Hg, and ARV / ARV was 11/7 mm Hg. With linear mixed models, 1- SD increases of ARV (standardized regression coefficient [95% confidence interval], -0.03 [-0.04 to -0.01] points) and ARV (standardized regression coefficient [95% confidence interval], -0.02 [-0.03 to -0.002] points; both P

DOI10.1161/JAHA.118.009578
Alternate JournalJ Am Heart Assoc
PubMed ID30371241
PubMed Central IDPMC6201456
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States