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Socioeconomic status and risk of kidney dysfunction: the Atherosclerosis Risk in Communities study.

TitleSocioeconomic status and risk of kidney dysfunction: the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2019
AuthorsVart P, Grams ME, Ballew SH, Woodward M, Coresh JJ
Secondary AuthorsMatsushita K
JournalNephrol Dial Transplant
Date Published2019 08 01
KeywordsAged, Atherosclerosis, Disease Progression, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic, Male, Middle Aged, Poverty, Proportional Hazards Models, Prospective Studies, Residence Characteristics, Risk Factors, Social Class

BACKGROUND: There is strong evidence of an association between socioeconomic status (SES) and end-stage renal disease (ESRD). However, the association of SES with the risk of chronic kidney disease (CKD) and the rate of change in kidney function is unclear.

METHODS: A cohort of 14 086 participants with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 at baseline in the Atherosclerosis Risk in Communities study (1987-89) were studied. The association of annual household income, educational attainment and neighborhood deprivation with incident ESRD, incident CKD and change in eGFR using four measurements over ∼23 years was assessed.

RESULTS: A total of 432 participants developed ESRD and 3510 developed CKD over a median follow-up time of ∼23 years. After adjustment for demographics and baseline eGFR, the hazard ratio (HR) for incident ESRD compared with the high-income group was 1.56 [95% confidence interval (CI) 1.22-1.99 in the medium-income group and 2.30 (95% CI 1.75-3.02) in the low-income group (P-trend 

CONCLUSIONS: SES (annual household income, educational attainment or neighborhood deprivation) was associated not only with ESRD risk but also with eGFR decline, although the association with CKD appeared weaker.

Alternate JournalNephrol Dial Transplant
PubMed ID29897587