Title | Socioeconomic status and risk of kidney dysfunction: the Atherosclerosis Risk in Communities study. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Vart P, Grams ME, Ballew SH, Woodward M, Coresh JJ |
Secondary Authors | Matsushita K |
Journal | Nephrol Dial Transplant |
Volume | 34 |
Issue | 8 |
Pagination | 1361-1368 |
Date Published | 2019 08 01 |
ISSN | 1460-2385 |
Keywords | Aged, Atherosclerosis, Disease Progression, Female, Follow-Up Studies, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic, Male, Middle Aged, Poverty, Proportional Hazards Models, Prospective Studies, Residence Characteristics, Risk Factors, Social Class |
Abstract | BACKGROUND: There is strong evidence of an association between socioeconomic status (SES) and end-stage renal disease (ESRD). However, the association of SES with the risk of chronic kidney disease (CKD) and the rate of change in kidney function is unclear. METHODS: A cohort of 14 086 participants with an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 at baseline in the Atherosclerosis Risk in Communities study (1987-89) were studied. The association of annual household income, educational attainment and neighborhood deprivation with incident ESRD, incident CKD and change in eGFR using four measurements over ∼23 years was assessed. RESULTS: A total of 432 participants developed ESRD and 3510 developed CKD over a median follow-up time of ∼23 years. After adjustment for demographics and baseline eGFR, the hazard ratio (HR) for incident ESRD compared with the high-income group was 1.56 [95% confidence interval (CI) 1.22-1.99 in the medium-income group and 2.30 (95% CI 1.75-3.02) in the low-income group (P-trend CONCLUSIONS: SES (annual household income, educational attainment or neighborhood deprivation) was associated not only with ESRD risk but also with eGFR decline, although the association with CKD appeared weaker. |
DOI | 10.1093/ndt/gfy142 |
Alternate Journal | Nephrol Dial Transplant |
PubMed ID | 29897587 |