|Title||Association of insulin resistance, from mid-life to late-life, with aortic stiffness in late-life: the Atherosclerosis Risk in Communities Study.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Poon AK, Meyer ML, Tanaka H, Selvin E, Pankow J, Zeng D, Loehr LR, Knowles JW, Rosamond WD|
|Secondary Authors||Heiss G|
|Date Published||2020 Jan 28|
|Keywords||Age Factors, Aged, Aging, Biomarkers, Blood Glucose, Cardiovascular Diseases, Cross-Sectional Studies, Female, Humans, Insulin, Insulin Resistance, Lipids, Male, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, United States, Vascular Stiffness|
BACKGROUND: Insulin resistance may contribute to aortic stiffening that leads to end-organ damage. We examined the cross-sectional association and prospective association of insulin resistance and aortic stiffness in older adults without diabetes.
METHODS: We analyzed 2571 men and women at Visit 5 (in 2011-2013), and 2350 men and women at repeat examinations from baseline at Visit 1 (in 1987-1989) to Visit 5 (in 2011-2013). Linear regression was used to estimate the difference in aortic stiffness per standard unit of HOMA-IR, TG/HDL-C, and TyG at Visit 5. Linear mixed effects were used to assess if high, as opposed to non-high, aortic stiffness (> 75th percentile) was preceded by a faster annual rate of change in log-HOMA-IR, log-TG/HDL-C, and log-TyG from Visit 1 to Visit 5.
RESULTS: The mean age of participants was 75 years, 37% (n = 957) were men, and 17% (n = 433) were African American. At Visit 5, higher HOMA-IR, higher TG/HDL-C, and higher TyG were associated with higher aortic stiffness (16 cm/s per SD (95% CI 6, 27), 29 cm/s per SD (95% CI 18, 40), and 32 cm/s per SD (95% CI 22, 42), respectively). From Visit 1 to Visit 5, high aortic stiffness, compared to non-high aortic stiffness, was not preceded by a faster annual rate of change in log-HOMA-IR from baseline to 9 years (0.030 (95% CI 0.024, 0.035) vs. 0.025 (95% CI 0.021, 0.028); p = 0.15) or 9 years onward (0.011 (95% CI 0.007, 0.015) vs. 0.011 (95% CI 0.009, 0.013); p = 0.31); in log-TG/HDL-C from baseline to 9 years (0.019 (95% CI 0.015, 0.024) vs. 0.024 (95% CI 0.022, 0.026); p = 0.06) or 9 years onward (- 0.007 (95% CI - 0.010, - 0.005) vs. - 0.009 (95% CI - 0.010, - 0.007); p = 0.08); or in log-TyG from baseline to 9 years (0.002 (95% CI 0.002, 0.003) vs. 0.003 (95% CI 0.003, 0.003); p = 0.03) or 9 years onward (0 (95% CI 0, 0) vs. 0 (95% CI 0, 0); p = 0.08).
CONCLUSIONS: Among older adults without diabetes, insulin resistance was associated with aortic stiffness, but the putative role of insulin resistance in aortic stiffness over the life course requires further study.
|Alternate Journal||Cardiovasc Diabetol|
|PubMed Central ID||PMC6986071|
|Grant List||P30DK116074 / / Stanford Diabetes Research Center / |
2 T32 HL 7055 / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
R01AG053938 / AG / NIA NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
R01 DK116750 / DK / NIDDK NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
1R01DK106236 / NH / NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
1R01HL135313 / NH / NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
P30 DK116074 / DK / NIDDK NIH HHS / United States