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Mid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study.

TitleMid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2019
AuthorsFashanu OE, Zhao D, Schneider ALC, Rawlings AM, Sharrett ARichey, Lutsey PL, Gottesman RF, Gross AL, Guallar E, Alonso A, Mosley TH
Secondary AuthorsMichos ED
JournalBMC Neurol
Volume19
Issue1
Pagination244
Date Published2019 Oct 22
ISSN1471-2377
KeywordsAfrican Americans, Aged, Cohort Studies, Cross-Sectional Studies, Dementia, European Continental Ancestry Group, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Vitamin D
Abstract

BACKGROUND: Activated Vitamin D has anti-inflammatory properties and adequate 25-hydroxyvitamin D [25(OH)D] concentrations may be important for neurocognitive function and protection against neurologic injury. We examined whether mid-life 25(OH) D concentrations were associated with later-life performance on neuropsychological testing, functional ability, depressive symptoms, and incident dementia.

METHODS: We studied 13,039 white and black ARIC participants who had serum 25(OH) D measured mid-life at visit 2 (1990-1992). Over the next ~ 20 years through visit 5 (2011-2013), participants underwent 3 additional in-person visits, annual telephone calls, and hospitalization surveillance. An extensive battery of neuropsychological outcomes were assessed at visit 5 using standardized protocols. Incident dementia was ascertained through a formal algorithm that included data from in-person cognitive testing, telephone interviews, hospital discharge codes, and death certificate codes. Diagnoses of dementia were adjudicated by expert clinician committee. For the primary cognitive analyses, we imputed for missing covariates and outcomes and used linear regression to evaluate non-concurrent cross-sectional associations of mid-life 25(OH) D (visit 2) with late-life neuropsychological outcomes (visit 5). We also used Cox regression models to examine associations of mid-life 25(OH) D and incident dementia.

RESULTS: In mid-life, the mean (SD) age of participants was 57 (6) years, 57% were women, and 24% black. Mean (SD) 25(OH) D was 24.3 (8.6) ng/mL; 33% had deficient (

CONCLUSION: In this community cohort, mid-life serum 25(OH) D concentrations were associated with incident dementia but not with performance on neuropsychological testing, functional ability, or depressive symptoms, 20 years later. Whether serum 25(OH) D concentrations are causally related to dementia or confounded by poorer health status remains uncertain.

TRIAL REGISTRATION: Registered on clinicaltrials.gov NCT00005131 .

DOI10.1186/s12883-019-1483-3
Alternate JournalBMC Neurol
PubMed ID31640594
PubMed Central IDPMC6805504
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
R01NS072243 / NS / NINDS NIH HHS / United States