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Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.

TitleMigraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.
Publication TypeJournal Article
Year of Publication2020
AuthorsGeorge KM, Folsom AR, Sharrett ARichey, Mosley TH, Gottesman RF, Hamedani AG
Secondary AuthorsLutsey PL
JournalHeadache
Volume60
Issue5
Pagination946-953
Date Published2020 05
ISSN1526-4610
Abstract

OBJECTIVE: We aimed to assess the association between migraine headache and incident dementia.

BACKGROUND: Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with increased risk of dementia. However, it is unknown whether migraine is independently associated with dementia.

METHODS: History of migraine was ascertained via questionnaire. Adjudicated cases of dementia were identified using cognitive tests, neuropsychological exams, and clinician review of suspected cases. Incident dementia was identified using adjudicated cases, follow-up calls, and surveillance of hospital and death codes. We assessed hazards of incident dementia by migraine status. Sex differences were also examined and stratified results were presented.

RESULTS: Analysis included 12,495 White and African American participants ages 51-70 with a median follow-up time of 21 years. Prevalence of dementia was 18.5% (1821/9955) among those with no migraine history, 15.8% (196/1243) among those with severe non-migraine heading, and 16.7% (233/1397) among migraineurs. There was no association between migraine and incident dementia [hazard ratio: 1.04 (0.91, 1.20)]. There was also no statistically significant interaction between sex and migraine status on risk of dementia.

CONCLUSION: Despite evidence of brain abnormalities in migraineurs, there was no association between migraine and incident dementia in this prospective cohort.

DOI10.1111/head.13794
Alternate JournalHeadache
PubMed ID32200562
PubMed Central IDPMC7192135
Grant List2U01HL096814 / NH / NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
R01-HL70825 / HL / NHLBI NIH HHS / United States
T32 NS061779-10 / NS / NINDS NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 2U01HL096812 / NH / NIH HHS / United States
T32 NS061779 / NS / NINDS NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
2U01HL096902 / NH / NIH HHS / United States
T32HL007779 / HL / NHLBI NIH HHS / United States
2U01HL096917 / NH / NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
2U01HL096899 / NH / NIH HHS / United States