Title | Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | George KM, Folsom AR, Sharrett ARichey, Mosley TH, Gottesman RF, Hamedani AG |
Secondary Authors | Lutsey PL |
Journal | Headache |
Volume | 60 |
Issue | 5 |
Pagination | 946-953 |
Date Published | 2020 05 |
ISSN | 1526-4610 |
Abstract | OBJECTIVE: We aimed to assess the association between migraine headache and incident dementia. BACKGROUND: Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with increased risk of dementia. However, it is unknown whether migraine is independently associated with dementia. METHODS: History of migraine was ascertained via questionnaire. Adjudicated cases of dementia were identified using cognitive tests, neuropsychological exams, and clinician review of suspected cases. Incident dementia was identified using adjudicated cases, follow-up calls, and surveillance of hospital and death codes. We assessed hazards of incident dementia by migraine status. Sex differences were also examined and stratified results were presented. RESULTS: Analysis included 12,495 White and African American participants ages 51-70 with a median follow-up time of 21Â years. Prevalence of dementia was 18.5% (1821/9955) among those with no migraine history, 15.8% (196/1243) among those with severe non-migraine heading, and 16.7% (233/1397) among migraineurs. There was no association between migraine and incident dementia [hazard ratio: 1.04 (0.91, 1.20)]. There was also no statistically significant interaction between sex and migraine status on risk of dementia. CONCLUSION: Despite evidence of brain abnormalities in migraineurs, there was no association between migraine and incident dementia in this prospective cohort. |
DOI | 10.1111/head.13794 |
Alternate Journal | Headache |
PubMed ID | 32200562 |
PubMed Central ID | PMC7192135 |
Grant List | 2U01HL096814 / NH / NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States R01-HL70825 / HL / NHLBI NIH HHS / United States T32 NS061779-10 / NS / NINDS NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States U01 2U01HL096812 / NH / NIH HHS / United States T32 NS061779 / NS / NINDS NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States T32 HL007779 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States 2U01HL096902 / NH / NIH HHS / United States T32HL007779 / HL / NHLBI NIH HHS / United States 2U01HL096917 / NH / NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States K24 AG052573 / AG / NIA NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States 2U01HL096899 / NH / NIH HHS / United States |