Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD.

TitleParticulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD.
Publication TypeJournal Article
Year of Publication2020
AuthorsBlum MF, Surapaneni A, Stewart JD, Liao D, Yanosky JD, Whitsel EA, Power MC
Secondary AuthorsGrams ME
JournalClin J Am Soc Nephrol
Volume15
Issue3
Pagination311-319
Date Published2020 03 06
ISSN1555-905X
Abstract

BACKGROUND AND OBJECTIVES: Exposure to particulate matter (PM)

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The study included 10,997 participants from the Atherosclerosis Risk in Communities cohort who were followed from 1996-1998 through 2016. Monthly mean PM concentrations (g/m) were estimated at geocoded participant addresses using geographic information system-based, spatiotemporal generalized additive mixed models-including geospatial covariates such as land use-and then averaged over the 12-month period preceding participant examination. Covariate-adjusted, cross-sectional associations of PM, baseline eGFR, and urinary albumin-creatinine ratio (UACR) were estimated using linear regression. PM and incident CKD (defined as follow-up eGFR

RESULTS: Baseline mean participant age was 63 (±6) years and eGFR was 86 (±16) ml/min per 1.73 m. There was no significant PM-eGFR association at baseline. Each 1-g/m higher annual average PM was associated with higher UACR after adjusting for demographics, socioeconomic status, and clinical covariates (percentage difference, 6.6%; 95% confidence interval [95% CI], 2.6% to 10.7%). Each 1-g/m higher annual average PM was associated with a significantly higher risk of incident CKD (hazard ratio, 1.05; 95% CI, 1.01 to 1.10).

CONCLUSIONS: Exposure to higher annual average PM concentrations was associated with a higher level of albuminuria and higher risk for incident CKD in a community-based cohort.

DOI10.2215/CJN.08350719
Alternate JournalClin J Am Soc Nephrol
PubMed ID32108020
PubMed Central IDPMC7057299
Grant ListHHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
R01 DK115534 / DK / NIDDK NIH HHS / United States
R01 ES020836 / ES / NIEHS NIH HHS / United States