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Atrial Fibrillation, Brain Volumes, and Subclinical Cerebrovascular Disease (from the Atherosclerosis Risk in Communities Neurocognitive Study [ARIC-NCS]).

TitleAtrial Fibrillation, Brain Volumes, and Subclinical Cerebrovascular Disease (from the Atherosclerosis Risk in Communities Neurocognitive Study [ARIC-NCS]).
Publication TypeJournal Article
Year of Publication2020
AuthorsMoazzami K, Shao IYuefan, Chen LYee, Lutsey PL, Jack CR, Mosley T, Joyner DA, Gottesman R
Secondary AuthorsAlonso A
JournalAm J Cardiol
Volume125
Issue2
Pagination222-228
Date Published2020 01 15
ISSN1879-1913
KeywordsAged, Atherosclerosis, Atrial Fibrillation, Brain, Cerebrovascular Disorders, Cognition, Female, Follow-Up Studies, Humans, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Prospective Studies, Risk Assessment, Risk Factors, United States
Abstract

The aim of the present study was to investigate the association between atrial fibrillation (AF) and total and regional brain volumes among participants in the community-based Atherosclerosis Risk in Communities Neurocognitive study (ARIC-NCS). A total of 1,930 participants (130 with AF) with a mean age of 76.3 ┬▒ 5.2, who underwent 3T brain MRI scans in 2011 to 2013 were included. Prevalent AF was ascertained from study ECGs and hospital discharge codes. Brain volumes were measured using FreeSurfer image analysis software. Markers of subclinical cerebrovascular disease included lobar microhemorrhages, subcortical microhemorrhages, cortical infarcts, subcortical infarcts, lacunar infarcts, and volume of white matter hyperintensities. Linear regression models were used to assess the associations between AF status and brain volumes. In adjusted analyses, AF was not associated with markers of subclinical cerebrovascular disease. However, AF was associated with smaller regional brain volumes (including temporal, occipital, and parietal lobes; deep gray matter; Alzheimer disease signature region; and hippocampus [all p

DOI10.1016/j.amjcard.2019.10.010
Alternate JournalAm J Cardiol
PubMed ID31771759
PubMed Central IDPMC6942172
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
T32 HL130025 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
K24 HL148521 / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States