Title | Atrial Fibrillation, Brain Volumes, and Subclinical Cerebrovascular Disease (from the Atherosclerosis Risk in Communities Neurocognitive Study [ARIC-NCS]). |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Moazzami K, Shao IYuefan, Chen LYee, Lutsey PL, Jack CR, Mosley T, Joyner DA, Gottesman R |
Secondary Authors | Alonso A |
Journal | Am J Cardiol |
Volume | 125 |
Issue | 2 |
Pagination | 222-228 |
Date Published | 2020 01 15 |
ISSN | 1879-1913 |
Keywords | Aged, Atherosclerosis, Atrial Fibrillation, Brain, Cerebrovascular Disorders, Cognition, Female, Follow-Up Studies, Humans, Incidence, Magnetic Resonance Imaging, Male, Middle Aged, Organ Size, Prospective Studies, Risk Assessment, Risk Factors, United States |
Abstract | The aim of the present study was to investigate the association between atrial fibrillation (AF) and total and regional brain volumes among participants in the community-based Atherosclerosis Risk in Communities Neurocognitive study (ARIC-NCS). A total of 1,930 participants (130 with AF) with a mean age of 76.3 ± 5.2, who underwent 3T brain MRI scans in 2011 to 2013 were included. Prevalent AF was ascertained from study ECGs and hospital discharge codes. Brain volumes were measured using FreeSurfer image analysis software. Markers of subclinical cerebrovascular disease included lobar microhemorrhages, subcortical microhemorrhages, cortical infarcts, subcortical infarcts, lacunar infarcts, and volume of white matter hyperintensities. Linear regression models were used to assess the associations between AF status and brain volumes. In adjusted analyses, AF was not associated with markers of subclinical cerebrovascular disease. However, AF was associated with smaller regional brain volumes (including temporal, occipital, and parietal lobes; deep gray matter; Alzheimer disease signature region; and hippocampus [all p |
DOI | 10.1016/j.amjcard.2019.10.010 |
Alternate Journal | Am J Cardiol |
PubMed ID | 31771759 |
PubMed Central ID | PMC6942172 |
Grant List | U01 HL096812 / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States 16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States U01 HL096902 / HL / NHLBI NIH HHS / United States T32 HL130025 / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States K24 HL148521 / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States |