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Resting heart rate and incidence of venous thromboembolism.

TitleResting heart rate and incidence of venous thromboembolism.
Publication TypeJournal Article
Year of Publication2020
AuthorsFolsom AR, Lutsey PL, Pope ZC, Fashanu OE, Misialek JR, Cushman M
Secondary AuthorsMichos ED
Corporate AuthorsAtherosclerosis Risk in Communities(ARIC) Study Investigators
JournalRes Pract Thromb Haemost
Date Published2020 Feb

Background/Objectives: Higher resting heart rate is a risk factor for arterial cardiovascular diseases. We assessed whether higher heart rate is a risk factor for venous thromboembolism (VTE).

Methods: In a prospective epidemiologic cohort, the Atherosclerosis Risk in Communities (ARIC) Study, we associated resting heart rate by electrocardiogram with physician-validated incident hospitalized VTE through 2015. We also examined whether lower heart rate variability (HRV), a marker of cardiac autonomic imbalance, might be a risk factor for VTE.

Results: Resting heart rate at Visit 1 (1987-1989), when participants were 45 to 64 years old (mean, 54 years), was not associated with incidence of VTE (n = 882 cases). However, heart rate at Visit 4 (1996-1998; mean age, 63 years) was associated positively with VTE (n = 557 cases). The adjusted hazard ratios (95% confidence intervals) of VTE across Visit 4 heart rate categories of

Conclusion: We found a significant positive and independent association of resting heart rate at ARIC Visit 4 with incidence of VTE. The reason why high heart rate is a risk marker for VTE warrants further exploration.

Alternate JournalRes Pract Thromb Haemost
PubMed ID32110754
PubMed Central IDPMC7040544