The association between midlife lipid levels and late-life brain amyloid deposition.

TitleThe association between midlife lipid levels and late-life brain amyloid deposition.
Publication TypeJournal Article
Year of Publication2020
AuthorsBennett EE, Gianattasio KZ, Hughes TM, Mosley TH, Wong DF, Gottesman RF
Secondary AuthorsPower MC
JournalNeurobiol Aging
Volume92
Pagination73-74
Date Published2020 08
ISSN1558-1497
KeywordsAmyloidogenic Proteins, Brain, Cholesterol, Cholesterol, HDL, Cholesterol, LDL, Dementia, Female, Humans, Male, Negative Results, Positron-Emission Tomography, Triglycerides
Abstract

Elevated low-density lipoprotein cholesterol and total cholesterol in midlife and decline in total cholesterol from mid- to late-life are associated with incident dementia. Whether brain amyloid deposition mediates this relationship is unclear. We explored the association between midlife blood lipid levels and mid- to late-life change in lipid levels with brain amyloid deposition assessed using florbetapir PET scans in a biracial sample of 325 nondemented participants of the Atherosclerosis Risk in Communities-PET Amyloid Imaging study. Midlife total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides were not significantly associated with late-life amyloid burden after adjusting for covariates. Associations between changes in lipids and late-life amyloid deposition were similarly null. Lipids may contribute to dementia risk through alternate mechanisms.

DOI10.1016/j.neurobiolaging.2020.03.015
Alternate JournalNeurobiol Aging
PubMed ID32402985
PubMed Central IDPMC7340169
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
R01 AG040282 / AG / NIA NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States