Physical Activity and Incident Heart Failure in High-Risk Subgroups: The ARIC Study.

TitlePhysical Activity and Incident Heart Failure in High-Risk Subgroups: The ARIC Study.
Publication TypeJournal Article
Year of Publication2020
AuthorsFlorido R, Kwak L, Lazo M, Michos ED, Nambi V, Blumenthal RS, Gerstenblith G, Palta P, Russell SD, Ballantyne CM, Selvin E, Folsom AR, Coresh JJ
Secondary AuthorsNdumele CE
JournalJ Am Heart Assoc
Volume9
Issue10
Paginatione014885
Date Published2020 05 18
ISSN2047-9980
Abstract

Background Greater physical activity (PA) is associated with lower heart failure (HF) risk. However, it is unclear whether this inverse association exists across all subgroups at high risk for HF, particularly among those with preexisting atherosclerotic cardiovascular disease. Methods and Results We followed 13 810 ARIC (Atherosclerosis Risk in Communities) study participants (mean age 55 years, 54% women, 26% black) without HF at baseline (visit 1; 1987-1989). PA was assessed using a modified Baecke questionnaire and categorized according to American Heart Association guidelines: recommended, intermediate, or poor. We constructed Cox models to estimate associations between PA categories and incident HF within each high-risk subgroup at baseline, with tests for interaction. We performed additional analyses modeling incident coronary heart disease as a time-varying covariate. Over a median of 26 years of follow-up, there were 2994 HF events. Compared with poor PA, recommended PA was associated with lower HF risk among participants with hypertension, obesity, diabetes mellitus, and metabolic syndrome (all

DOI10.1161/JAHA.119.014885
Alternate JournalJ Am Heart Assoc
PubMed ID32390492
PubMed Central IDPMC7660876
Grant ListK24 DK106414 / DK / NIDDK NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
R01 HL134320 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
R01 HL146907 / HL / NHLBI NIH HHS / United States