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Risk of Ischemic Stroke Increases Over the Spectrum of Metabolic Syndrome Severity.

TitleRisk of Ischemic Stroke Increases Over the Spectrum of Metabolic Syndrome Severity.
Publication TypeJournal Article
Year of Publication2020
AuthorsDeBoer MD, Filipp SL, Sims M, Musani SK
Secondary AuthorsGurka MJ
Date Published2020 08
KeywordsBrain Ischemia, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Metabolic Syndrome, Middle Aged, Risk Factors, Severity of Illness Index, Stroke

BACKGROUND AND PURPOSE: Ischemic stroke is associated with the metabolic syndrome (MetS) as diagnosed using dichotomous criteria; however, these criteria exhibit racial/ethnic discrepancies. Our goal was to assess whether ischemic stroke risk extended over the spectrum of worsening MetS severity using a sex- and race/ethnicity-specific MetS-severity score.

METHODS: We used Cox-proportional hazards models to assess the relationship between baseline MetS- score and incident ischemic stroke among participants of the Atherosclerosis Risk in Communities study and Jackson Heart Study who were free from diabetes, coronary heart disease or stroke at baseline, evaluating 13 141 white and black individuals with mean follow-up of 18.6 years.

RESULTS: We found that risk of ischemic stroke increased consistently with MetS severity, with a hazard ratio of 1.75 (95% CI, 1.35-2.27) for those >75th percentile compared to those

CONCLUSIONS: Ischemic stroke risk increased over the spectrum of MetS severity in the absence of baseline diabetes mellitus, further implicating potential etiologic risks from processes underlying MetS. Individuals with elevated MetS severity should be counselled toward lifestyle modification to lower ischemic stroke risk.

Alternate JournalStroke
PubMed ID32552367
PubMed Central IDPMC7428063
Grant ListR01 HL120960 / HL / NHLBI NIH HHS / United States
HHSN268201300046C / HL / NHLBI NIH HHS / United States
HHSN268201300047C / HL / NHLBI NIH HHS / United States
HHSN268201300048C / HL / NHLBI NIH HHS / United States
HHSN268201300049C / HL / NHLBI NIH HHS / United States