|Title||Association between kidney disease measures and intracranial atherosclerosis: The ARIC study.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Hao Q, Gottesman RF, Qiao Y, Liu L, Sharma R, Selvin E, Matsushita K, Coresh JJ|
|Secondary Authors||Wasserman BA|
|Date Published||2020 06 02|
|Keywords||Aged, Aged, 80 and over, Cohort Studies, Cross-Sectional Studies, Female, Glomerular Filtration Rate, Humans, Independent Living, Intracranial Arteriosclerosis, Kidney Function Tests, Male, Mental Status and Dementia Tests, Prospective Studies, Renal Insufficiency, Chronic, Risk Factors|
OBJECTIVE: To test the association between reduced kidney function (assessed by estimated glomerular filtration rate [eGFR] and cystatin C [CysC]) and kidney damage (assessed by urinary albumin-to-creatinine ratio [ACR]) and intracranial atherosclerotic disease (ICAD) by high-resolution vessel wall MRI (VWMRI) in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).
METHODS: We conducted a cross-sectional analysis of ARIC participants with data on kidney measures and VWMRI in 2011 to 2013. The main outcomes were presence of intracranial plaques and luminal stenosis. Multivariable models were adjusted for demographics, cardiovascular risk factors, and use of antithrombotic medications.
RESULTS: A total of 1,762 participants (mean ± SD age, 76.3 ± 5.3) were included. eGFR based on CysC (eGFRcysc) 70% stenosis or occlusion (adjusted OR 2.15, 95% CI 1.32-3.50). Neither ACR nor CysC showed statistically significant associations with ICAD features in adjusted models. In adjusted multinomial models, participants with eGFRcysc
CONCLUSION: In community-dwelling older adults, reduced kidney function or elevated kidney damage was associated with ICAD measured by VWMRI. This finding may help to better identify a population at high risk for ICAD.
|PubMed Central ID||PMC7357292|
|Grant List||K24 DK106414 / DK / NIDDK NIH HHS / United States |
R01 DK089174 / DK / NIDDK NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
K99 HL106232 / HL / NHLBI NIH HHS / United States
R25 NS079211 / NS / NINDS NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States