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Mid- to Late-Life Time-Averaged Cumulative Blood Pressure and Late-Life Cardiac Structure, Function, and Heart Failure.

TitleMid- to Late-Life Time-Averaged Cumulative Blood Pressure and Late-Life Cardiac Structure, Function, and Heart Failure.
Publication TypeJournal Article
Year of Publication2020
AuthorsTeramoto K, Junior WNadruz, Matsushita K, Claggett B, John JE, Skali H, Solomon S, Cheng S
Secondary AuthorsShah AM
JournalHypertension
Volume76
Issue3
Pagination808-818
Date Published2020 Sep
ISSN1524-4563
Abstract

Limited data exist regarding systolic blood pressure (SBP) through mid- to late-life and late-life cardiac function and heart failure (HF) risk. Among 4578 HF-free participants in the ARIC study (Atherosclerosis Risk in Communities) attending the fifth visit (2011-2013; age 75±5 years), time-averaged cumulative SBP was calculated as the sum of averaged SBPs from adjacent consecutive visits (visits 1-5) indexed to total observation time (24±1 years). Calculations were performed using measured SBPs and also incorporating antihypertensive medication specific effect constants (underlying SBP). Outcomes included comprehensive echocardiography at visit 5 and post-visit 5 incident HF, HF with preserved ejection fraction, and reduced ejection fraction. Higher cumulative SBP was associated with greater left ventricular mass and worse diastolic measures (all

DOI10.1161/HYPERTENSIONAHA.120.14833
Alternate JournalHypertension
PubMed ID32536273