Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.

TitleGenome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke.
Publication TypeJournal Article
Year of Publication2020
AuthorsKeene KL, Hyacinth HI, Bis JC, Kittner SJ, Mitchell BD, Cheng Y-C, Paré G, Chong M, O'Donnell M, Meschia JF, Chen W-M, Sale MM, Rich SS, Nalls MA, Zonderman AB, Evans MK, Wilson JG, Correa A, Markus HS, Traylor M, Lewis CM, Carty CL, Reiner A, Haessler J, Langefeld CD, Gottesman R, Mosley TH, Woo D, Yaffe K, Liu Y, Longstreth WT, Psaty BM, Kooperberg C, Lange LA, Sacco R, Rundek T, Lee J-M, Cruchaga C, Furie KL, Arnett DK, Benavente OR, Grewal RP, Peddareddygari LReddy, Dichgans M, Malik R, Worrall BB
Secondary AuthorsFornage M
Corporate AuthorsCOMPASS, SiGN, and METASTROKE Consortia
JournalStroke
Volume51
Issue8
Pagination2454-2463
Date Published2020 08
ISSN1524-4628
KeywordsAfrican Americans, Cohort Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Stroke
Abstract

BACKGROUND AND PURPOSE: Stroke is a complex disease with multiple genetic and environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to 3× more likely to die from stroke than European Americans.

METHODS: The COMPASS (Consortium of Minority Population Genome-Wide Association Studies of Stroke) has conducted a genome-wide association meta-analysis of stroke in >22 000 individuals of African ancestry (3734 cases, 18 317 controls) from 13 cohorts.

RESULTS: In meta-analyses, we identified one single nucleotide polymorphism (rs55931441) near the gene that reached genome-wide significance (=4.62×10) and an additional 29 variants with suggestive evidence of association (

CONCLUSIONS: These findings represent the most thorough investigation of genetic determinants of stroke in individuals of African descent, to date.

DOI10.1161/STROKEAHA.120.029123
Alternate JournalStroke
PubMed ID32693751
PubMed Central IDPMC7387190
Grant ListU01 HG005160 / HG / NHGRI NIH HHS / United States
R01 HL103612 / HL / NHLBI NIH HHS / United States
R01 HL086694 / HL / NHLBI NIH HHS / United States
R01 HL087652 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 NS039987 / NS / NINDS NIH HHS / United States
U01 NS041588 / NS / NINDS NIH HHS / United States
R01 HL138423 / HL / NHLBI NIH HHS / United States
R01 NS045012 / NS / NINDS NIH HHS / United States
Z01 AG000513 / ImNIH / Intramural NIH HHS / United States
R01 NS042733 / NS / NINDS NIH HHS / United States
U01 HG004446 / HG / NHGRI NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
L60 MD013112 / MD / NIMHD NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
Z01 AG000954 / ImNIH / Intramural NIH HHS / United States
R01 DK084350 / DK / NIDDK NIH HHS / United States
P30 DK072488 / DK / NIDDK NIH HHS / United States
U01 NS069208 / NS / NINDS NIH HHS / United States
R01 NS034447 / NS / NINDS NIH HHS / United States
U01 HG004436 / HG / NHGRI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States