Title | Associations of autozygosity with a broad range of human phenotypes. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Clark DW, Okada Y, Moore KHS, et al. |
Secondary Authors | Wilson JF |
Journal | Nat Commun |
Volume | 10 |
Issue | 1 |
Pagination | 4957 |
Date Published | 2019 10 31 |
ISSN | 2041-1723 |
Keywords | Alleles, Body Size, Cognition, Consanguinity, Fertility, Haplotypes, Health Status, Homozygote, Humans, Inbreeding Depression, Risk-Taking |
Abstract | In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F) for >1.4 million individuals, we show that F is significantly associated (p  |
DOI | 10.1038/s41467-019-12283-6 |
Alternate Journal | Nat Commun |
PubMed ID | 31673082 |
PubMed Central ID | PMC6823371 |
Grant List | 212946/Z/18/Z / WT_ / Wellcome Trust / United Kingdom MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom MC_QA137853 / MRC_ / Medical Research Council / United Kingdom MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom G0401527 / MRC_ / Medical Research Council / United Kingdom MC_UU_00017/1 / MRC_ / Medical Research Council / United Kingdom MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom T32 DK091317 / DK / NIDDK NIH HHS / United States R01 AG015819 / AG / NIA NIH HHS / United States R01 DK093757 / DK / NIDDK NIH HHS / United States MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom MC_U137686851 / MRC_ / Medical Research Council / United Kingdom G9521010 / MRC_ / Medical Research Council / United Kingdom MC_UU_00011/7 / MRC_ / Medical Research Council / United Kingdom R01 DK072193 / DK / NIDDK NIH HHS / United States MR/N024397/1 / MRC_ / Medical Research Council / United Kingdom CS/16/4/32482 / BHF_ / British Heart Foundation / United Kingdom MC_UU_12026/2 / MRC_ / Medical Research Council / United Kingdom MC_PC_14089 / MRC_ / Medical Research Council / United Kingdom MC_UU_00011/1 / MRC_ / Medical Research Council / United Kingdom R01 AG017917 / AG / NIA NIH HHS / United States MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom R01 HL119443 / HL / NHLBI NIH HHS / United States R01 DK062370 / DK / NIDDK NIH HHS / United States MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom MC_PC_14135 / MRC_ / Medical Research Council / United Kingdom P30 AG010161 / AG / NIA NIH HHS / United States 14136 / CRUK_ / Cancer Research UK / United Kingdom MC_PC_U127592696 / MRC_ / Medical Research Council / United Kingdom MC_EX_MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom MC_UU_00011/6 / MRC_ / Medical Research Council / United Kingdom U01 DK062370 / DK / NIDDK NIH HHS / United States K99 HD099330 / HD / NICHD NIH HHS / United States MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom U01 CA182913 / CA / NCI NIH HHS / United States G9815508 / MRC_ / Medical Research Council / United Kingdom FS/12/82/29736 / BHF_ / British Heart Foundation / United Kingdom MC_PC_13049 / MRC_ / Medical Research Council / United Kingdom |