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Associations of autozygosity with a broad range of human phenotypes.

TitleAssociations of autozygosity with a broad range of human phenotypes.
Publication TypeJournal Article
Year of Publication2019
AuthorsClark DW, Okada Y, Moore KHS, et al.
Secondary AuthorsWilson JF
JournalNat Commun
Volume10
Issue1
Pagination4957
Date Published2019 10 31
ISSN2041-1723
KeywordsAlleles, Body Size, Cognition, Consanguinity, Fertility, Haplotypes, Health Status, Homozygote, Humans, Inbreeding Depression, Risk-Taking
Abstract

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F) for >1.4 million individuals, we show that F is significantly associated (p 

DOI10.1038/s41467-019-12283-6
Alternate JournalNat Commun
PubMed ID31673082
PubMed Central IDPMC6823371
Grant List212946/Z/18/Z / WT_ / Wellcome Trust / United Kingdom
MR/N003284/1 / MRC_ / Medical Research Council / United Kingdom
MC_QA137853 / MRC_ / Medical Research Council / United Kingdom
MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom
G0401527 / MRC_ / Medical Research Council / United Kingdom
MC_UU_00017/1 / MRC_ / Medical Research Council / United Kingdom
MR/R023484/1 / MRC_ / Medical Research Council / United Kingdom
T32 DK091317 / DK / NIDDK NIH HHS / United States
R01 AG015819 / AG / NIA NIH HHS / United States
R01 DK093757 / DK / NIDDK NIH HHS / United States
MC_UU_00007/10 / MRC_ / Medical Research Council / United Kingdom
MC_U137686851 / MRC_ / Medical Research Council / United Kingdom
G9521010 / MRC_ / Medical Research Council / United Kingdom
MC_UU_00011/7 / MRC_ / Medical Research Council / United Kingdom
R01 DK072193 / DK / NIDDK NIH HHS / United States
MR/N024397/1 / MRC_ / Medical Research Council / United Kingdom
CS/16/4/32482 / BHF_ / British Heart Foundation / United Kingdom
MC_UU_12026/2 / MRC_ / Medical Research Council / United Kingdom
MC_PC_14089 / MRC_ / Medical Research Council / United Kingdom
MC_UU_00011/1 / MRC_ / Medical Research Council / United Kingdom
R01 AG017917 / AG / NIA NIH HHS / United States
MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom
R01 HL119443 / HL / NHLBI NIH HHS / United States
R01 DK062370 / DK / NIDDK NIH HHS / United States
MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom
MC_PC_14135 / MRC_ / Medical Research Council / United Kingdom
P30 AG010161 / AG / NIA NIH HHS / United States
14136 / CRUK_ / Cancer Research UK / United Kingdom
MC_PC_U127592696 / MRC_ / Medical Research Council / United Kingdom
MC_EX_MR/M009203/1 / MRC_ / Medical Research Council / United Kingdom
MC_UU_00011/6 / MRC_ / Medical Research Council / United Kingdom
U01 DK062370 / DK / NIDDK NIH HHS / United States
K99 HD099330 / HD / NICHD NIH HHS / United States
MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
U01 CA182913 / CA / NCI NIH HHS / United States
G9815508 / MRC_ / Medical Research Council / United Kingdom
FS/12/82/29736 / BHF_ / British Heart Foundation / United Kingdom
MC_PC_13049 / MRC_ / Medical Research Council / United Kingdom