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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

TitleGene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
Publication TypeJournal Article
Year of Publication2020
AuthorsFuentes Lde Las, Sung YJu, Noordam R, et al.
Secondary AuthorsFornage M
Corporate AuthorsLifeLines Cohort Study
JournalMol Psychiatry
Date Published2020 May 05
ISSN1476-5578
Abstract

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P 

DOI10.1038/s41380-020-0719-3
Alternate JournalMol Psychiatry
PubMed ID32372009
PubMed Central IDPMC7641978
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