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Glycaemic markers and all-cause mortality in older adults with and without diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

TitleGlycaemic markers and all-cause mortality in older adults with and without diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
Publication TypeJournal Article
Year of Publication2020
AuthorsRooney MR, Tang O, Pankow JS
Secondary AuthorsSelvin E
JournalDiabetologia
Date Published2020 Sep 29
ISSN1432-0428
Abstract

AIMS/HYPOTHESIS: There is controversy regarding the performance of HbA in old age. We evaluated the prognostic value of HbA and other glycaemic markers (fructosamine, glycated albumin, fasting glucose) with mortality risk in older adults (66-90 years).

METHODS: This was a prospective analysis of 5636 participants (31% with diagnosed diabetes, mean age 76, 58% female, 21% black) in the Atherosclerosis Risk in Communities (ARIC) study, baseline 2011-2013. We used Cox regression to examine associations of glycaemic markers (modelled in categories) with mortality risk, stratified by diagnosed diabetes status.

RESULTS: During a median of 6 years of follow-up, 983 deaths occurred. Among older adults with diabetes, 30% had low HbA (

CONCLUSIONS/INTERPRETATION: Elevated HbA, fructosamine, glycated albumin and fasting glucose were associated with risk of mortality in older adults with diabetes. Low HbA and fasting glucose may be markers of poor prognosis but are possibly confounded by health status. Our findings support the clinical use of HbA in older adults with diabetes. Graphical abstract.

DOI10.1007/s00125-020-05285-3
Alternate JournalDiabetologia
PubMed ID32990802
Grant ListF30 DK120160 / DK / NIDDK NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
T32HL007024 / HL / NHLBI NIH HHS / United States
R01DK089174 / DK / NIDDK NIH HHS / United States