|Title||Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Justice AE, Chittoor G, Gondalia R, Melton PE, Lim E, Grove ML, Whitsel EA, Liu C-T, L Cupples A, Fernández-Rhodes L, Guan W, Bressler J, Fornage M, Boerwinkle E, Li Y, Demerath EW, Heard-Costa N, Levy D, Stewart JD, Baccarelli A, Hou L, Conneely K, Mori TA, Beilin LJ, Huang R-C, Gordon-Larsen P, Howard AGreen|
|Secondary Authors||North KE|
|Date Published||2020 Sep|
We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820). We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations near , , and that had not previously been associated with obesity-related traits.