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Low Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study.

TitleLow Liver Enzymes and Risk of Dementia: The Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2021
AuthorsLu Y, Pike JR, Selvin E, Mosley T, Palta P, A Sharrett R, Thomas A, Loehr L, A Barritt S, Hoogeveen RC, Heiss G
JournalJ Alzheimers Dis
Date Published2021

BACKGROUND: Low levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the low physiologic range, surrogate markers for reduced liver metabolic function, are associated with cerebral hypometabolism, impairment in neurotransmitter production and synaptic maintenance, and a higher prevalence of dementia. It is unknown whether a prospective association exists between low liver enzyme levels and incident dementia.

OBJECTIVE: To determine whether low levels of ALT and AST are associated with higher risk of incident dementia.

METHODS: Plasma ALT and AST were measured on 10,100 study participants (mean age 63.2 years, 55% female, 22% black) in 1996-1998. Dementia was ascertained from comprehensive neuropsychological assessments, annual contact, and medical record surveillance. Cox proportional hazards regression was used to estimate the association.

RESULTS: During a median follow-up of 18.3 years (maximum 21.9 years), 1,857 individuals developed dementia. Adjusted for demographic factors, incidence rates of dementia were higher at the lower levels of ALT and AST. Compared to the second quintile, ALT values

CONCLUSION: Plasma aminotransferases

Alternate JournalJ Alzheimers Dis
PubMed ID33459646
Grant ListK24 HL152440 / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States