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Six-year changes in N-terminal pro-brain natriuretic peptide and changes in weight and risk of obesity.

TitleSix-year changes in N-terminal pro-brain natriuretic peptide and changes in weight and risk of obesity.
Publication TypeJournal Article
Year of Publication2021
Authorsda Silva MSbaraini, Lazo M, Daya NR, Tang O, Schaan BD, Ballantyne CM, Ndumele C, Selvin E
JournalObesity (Silver Spring)
Volume29
Issue7
Pagination1215-1222
Date Published2021 Jul
ISSN1930-739X
Abstract

OBJECTIVE: The aim of this study was to study the prospective association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and changes in weight and obesity risk in a community-based population.

METHODS: Data from 9,681 participants from the Atherosclerosis Risk in Communities Study were analyzed at two time points 6 years apart. Among people without obesity at baseline, multivariable logistic regression models were used to examine the association between baseline levels of NT-proBNP and incident obesity. A multivariable linear regression model was used to examine the association between changes in NT-proBNP (visit 2 serum and visit 4 plasma samples) and changes in weight.

RESULTS: The prevalence of obesity increased from 28% to 35% in the 6-year follow-up period. Compared with individuals in the highest NT-proBNP quartile, those in the lowest were more likely to have obesity at baseline (odds ratio 1.25; 95% CI: 1.08-1.45) and, among people who did not have obesity at baseline, were more likely to develop obesity at follow-up (odds ratio 1.35; 95% CI: 1.07-1.69). Changes in NT-proBNP were inversely associated with weight change.

CONCLUSIONS: In this prospective study, lower levels of NT-proBNP were associated with higher risk of obesity, and changes in NT-proBNP were inversely associated with changes in weight. This suggests that natriuretic peptides or their pathways may be potential targets in the treatment of obesity.

DOI10.1002/oby.23181
Alternate JournalObesity (Silver Spring)
PubMed ID34159759
PubMed Central IDPMC8231730
Grant ListK24 HL152440 / HL / NHLBI NIH HHS / United States
HHSN268201700002C / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
/ / Conselho Nacional de Desenvolvimento Científico e Tecnológico /
F30 DK120160 / DK / NIDDK NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
R01 HL134320 / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
/ / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior /
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
R01DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
F30DK120160 / DK / NIDDK NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States