Title | Six-year changes in N-terminal pro-brain natriuretic peptide and changes in weight and risk of obesity. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | da Silva MSbaraini, Lazo M, Daya NR, Tang O, Schaan BD, Ballantyne CM, Ndumele C, Selvin E |
Journal | Obesity (Silver Spring) |
Volume | 29 |
Issue | 7 |
Pagination | 1215-1222 |
Date Published | 2021 Jul |
ISSN | 1930-739X |
Abstract | OBJECTIVE: The aim of this study was to study the prospective association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and changes in weight and obesity risk in a community-based population. METHODS: Data from 9,681 participants from the Atherosclerosis Risk in Communities Study were analyzed at two time points 6 years apart. Among people without obesity at baseline, multivariable logistic regression models were used to examine the association between baseline levels of NT-proBNP and incident obesity. A multivariable linear regression model was used to examine the association between changes in NT-proBNP (visit 2 serum and visit 4 plasma samples) and changes in weight. RESULTS: The prevalence of obesity increased from 28% to 35% in the 6-year follow-up period. Compared with individuals in the highest NT-proBNP quartile, those in the lowest were more likely to have obesity at baseline (odds ratio 1.25; 95% CI: 1.08-1.45) and, among people who did not have obesity at baseline, were more likely to develop obesity at follow-up (odds ratio 1.35; 95% CI: 1.07-1.69). Changes in NT-proBNP were inversely associated with weight change. CONCLUSIONS: In this prospective study, lower levels of NT-proBNP were associated with higher risk of obesity, and changes in NT-proBNP were inversely associated with changes in weight. This suggests that natriuretic peptides or their pathways may be potential targets in the treatment of obesity. |
DOI | 10.1002/oby.23181 |
Alternate Journal | Obesity (Silver Spring) |
PubMed ID | 34159759 |
PubMed Central ID | PMC8231730 |
Grant List | K24 HL152440 / HL / NHLBI NIH HHS / United States HHSN268201700002C / HL / NHLBI NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States / / Conselho Nacional de Desenvolvimento Científico e Tecnológico / F30 DK120160 / DK / NIDDK NIH HHS / United States HHSN268201700004C / HL / NHLBI NIH HHS / United States R01 HL134320 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States / / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / R01 DK089174 / DK / NIDDK NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States R01DK089174 / DK / NIDDK NIH HHS / United States HHSN268201700005C / HL / NHLBI NIH HHS / United States HHSN268201700001C / HL / NHLBI NIH HHS / United States HHSN268201700003C / HL / NHLBI NIH HHS / United States F30DK120160 / DK / NIDDK NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States |