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Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-modified Association.

TitlePeriodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-modified Association.
Publication TypeJournal Article
Year of Publication2021
AuthorsZhang S, Philips KH, Moss K, Wu D, Adam HS, Selvin E, Demmer RT, Norby FL, Mustapha IZ, Beck JD
JournalJ Clin Endocrinol Metab
Date Published2021 May 13
ISSN1945-7197
Abstract

PURPOSE: To determine whether periodontal disease is positively associated with incident diabetes across the continuum of body mass levels (BMI) and test the hypothesis that the periodontal risk for incident diabetes is modified by BMI.

METHODS: We included 5569 diabetes-free participants from Visit 4 (1996-1998) of the Atherosclerosis Risk in Communities (ARIC) Study and followed them until 2018. Periodontal disease status was classified by periodontal profile class (PPC)-Stages and incident diabetes was based on participant report of physician diagnosis. We estimated the hazard ratios (HR) for diabetes using a competing risk model for each PPC-Stage. We assessed multiplicative interactions between periodontal disease and BMI (as a continuous variable) on risk of diabetes.

RESULTS: During a median time of 19.4 years of follow-up, 1,348 incident diabetes cases and 1,529 deaths occurred. Compared to "healthy/incidental disease" Stage , participants with PPC-"severe periodontal disease" or "severe tooth loss" Stage and lower BMI had elevated risk for diabetes adjusting for demographic, smoking, education and biological variables when accounting for death as a competing risk with HRs 1.76 (95%CI 1.10-2.80) and 2.11 (95% CI 1.46-3.04), respectively. The interaction between PPC-stages and BMI was significant (p= 0.01). No significant associations of PPC-Stages with incident diabetes were present when BMI was above 31 kg/m 2.

CONCLUSION: Periodontal disease was associated with incident diabetes, especially in non-obese participants. Dentists should be aware that periodontal disease is associated with incident diabetes but the association may be modified for patient's at higher BMI levels.

DOI10.1210/clinem/dgab337
Alternate JournalJ Clin Endocrinol Metab
PubMed ID33982107
PubMed Central IDPMC8372648
Grant ListK24 HL152440 / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
R00 DE027086 / DE / NIDCR NIH HHS / United States
HHSN268201700002C / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States