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Association of arterial stiffness with incident atrial fibrillation: a cohort study.

TitleAssociation of arterial stiffness with incident atrial fibrillation: a cohort study.
Publication TypeJournal Article
Year of Publication2021
AuthorsAlmuwaqqat Z, Claxton J'Neka S, Norby FL, Lutsey PL, Wei J, Soliman EZ, Chen LY, Matsushita K, Heiss G, Alonso A
JournalBMC Cardiovasc Disord
Date Published2021 May 20

BACKGROUND: Stiff arteries increase left ventricular (LV) end-systolic workload, leading over time to left atrial and ventricular remodeling, and providing the substrate for atrial fibrillation (AF) development. We investigated if carotid femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness, is associated with incident AF.

METHODS: In 2011-2013, cfPWV was measured in 3882 participants of the Atherosclerosis Risk in Communities Cohort Study (ARIC) without prevalent AF. Participants were followed through 2017 for the incidence of AF. Individuals were categorized in cfPWV quartiles based on visit measurements. Multivariable Cox regression models were used to evaluate the association of cfPWV with incident AF.

RESULTS: Mean age was 75 years (SD 5), 60% were female and 20% were African American. Over a median follow-up of 5.5 years we identified 331 incident cases of AF. cfPWV demonstrated U-shaped associations with AF risk. In models adjusted for age, race, center, sex, education levels, and hemodynamic and clinical factors, hazard ratios (HR) of AF for participants in the first, third and fourth quartiles were 1.49 (95% CI 1.06, 2.10), 1.59 (1.14, 2.10), and 1.56(1.10, 2.19), respectively, compared to those in the second quartile.

CONCLUSION: Among community-dwelling older adults, low and high central arterial stiffness is associated with AF risk.

Alternate JournalBMC Cardiovasc Disord
PubMed ID34016038
PubMed Central IDPMC8139144
Grant ListK24 HL148521 / HL / NHLBI NIH HHS / United States