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Glucose Patterns in Very Old Adults: A Pilot Study in a Community-Based Population.

TitleGlucose Patterns in Very Old Adults: A Pilot Study in a Community-Based Population.
Publication TypeJournal Article
Year of Publication2021
AuthorsSelvin E, Wang D, Tang O, Minotti M, Echouffo-Tcheugui JB, Coresh J
JournalDiabetes Technol Ther
Date Published2021 Aug 19
ISSN1557-8593
Abstract

Continuous glucose monitoring (CGM) provides nuanced information on glucose patterns, but data in very old adults are scarce. To evaluate CGM patterns in very old adults. Pilot study. Participants recruited from one center during visit 7 (2019) of the community-based Atherosclerosis Risk in Communities (ARIC) Study. We enrolled 27 adults (8 with type 2 diabetes and 19 without diabetes) who wore a CGM sensor (Abbott Libre Pro) for up to 14 days. Clinical and laboratory measures, including hemoglobin A1c (HbA1c), were obtained. Mean CGM glucose, standard deviation (SD), coefficient of variation (CV), time-in-range (TIR) 70-180 mg/dL, and hypoglycemia. Mean age was 81 (range 77-91 years) and mean CGM wear time was 13.2 days. In persons without diabetes, there was a wide range of CGM parameters: range of mean glucose, 83.7-124.5 mg/dL, SD 12.2-27.3 mg/dL, CV 14.0%-26.7%, and TIR 71.1%-99.5%. In persons with diabetes, the range of mean CGM glucose was 105.5-223.0 mg/dL, SD, 22.3-86.6 mg/dL, CV 18.2%-38.8%, TIR 38.7%-98.3%. The Pearson's correlation of mean glucose with HbA1c was high overall (0.90); but, for some participants with similar HbA1c, glucose patterns differed substantially. There was a high prevalence of hypoglycemia (glucose

DOI10.1089/dia.2021.0156
Alternate JournalDiabetes Technol Ther
PubMed ID34191599
Grant ListK24 DK106414 / DK / NIDDK NIH HHS / United States
R01 DK128837 / DK / NIDDK NIH HHS / United States