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No prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence.

TitleNo prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence.
Publication TypeJournal Article
Year of Publication2021
AuthorsFolsom AR, de Vries PS, Cushman M
JournalJ Thromb Haemost
Date Published2021 Aug 19
ISSN1538-7836
Abstract

BACKGROUND: Previous studies are inconsistent about whether chronic coronary artery disease or generalized atherosclerosis is a causal risk factor for venous thromboembolism. No study seems to have taken a genomic approach to this question.

OBJECTIVE: To test in a prospective study whether a polygenic risk score for coronary artery disease is associated with risk of venous thromboembolism.

PARTICIPANTS/METHODS: Within the Atherosclerosis Risk in Communities Study cohort, we computed a previously validated polygenic risk score for coronary artery disease among 9144 White participants at baseline in 1987-1989. We followed the participants through 2015 for incident hospitalized venous thromboembolism events, validated by physician review. We used Cox proportional hazards regression to associate quintiles of the polygenic risk score to venous thromboembolism incidence rates.

RESULTS: Over the median of 26 years of follow-up, 476 participants had a venous thromboembolism event. There was no apparent association between the coronary artery disease polygenic risk score and incident venous thromboembolism, with age, sex, body mass index adjusted hazard ratios across quintiles being 1 (reference), 0.87 (0.65, 1.15), 1.08 (0.82, 1.42), 0.96 (0.72, 1.27), and 1.03 (0.78, 1.37).

CONCLUSIONS: A genetic disposition to coronary artery disease did not confer an increased risk of venous thromboembolism in this prospective study.

DOI10.1111/jth.15501
Alternate JournalJ Thromb Haemost
PubMed ID34409733
Grant ListHHSN268200625226C / NH / NIH HHS / United States
UL1RR025005 / NH / NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
R01HL087641 / / National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services /
R01HL059367 / / National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services /
R01HL086694 / / National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services /
18CDA34110116 / / American Heart Association /