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Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.

TitleGlobal and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.
Publication TypeJournal Article
Year of Publication2020
AuthorsShin J, Ma S, Hofer E, Patel Y, Vosberg DE, Tilley S, Roshchupkin GV, Sousa AMM, Jian X, Gottesman R, Mosley TH, Fornage M, Saba Y, Pirpamer L, Schmidt R, Schmidt H, Carrion-Castillo A, Crivello F, Mazoyer B, Bis JC, Li S, Yang Q, Luciano M, Karama S, Lewis L, Bastin ME, Harris MA, Wardlaw JM, Deary IE, Scholz M, Loeffler M, A Witte V, Beyer F, Villringer A, Armstrong NJ, Mather KA, Ames D, Jiang J, Kwok JB, Schofield PR, Thalamuthu A, Trollor JN, Wright MJ, Brodaty H, Wen W, Sachdev PS, Terzikhan N, Evans TE, Adams HHHH, M Ikram A, Frenzel S, van der Auwera-Palitschka S, Wittfeld K, Bülow R, Grabe HJörgen, Tzourio C, Mishra A, Maingault S, Debette S, Gillespie NA, Franz CE, Kremen WS, Ding L, Jahanshad N, Sestan N, Pausova Z, Seshadri S, Paus T
Corporate AuthorsENIGMA Consortium, neuroCHARGE Working Group
JournalCereb Cortex
Volume30
Issue7
Pagination4121-4139
Date Published2020 06 01
ISSN1460-2199
Abstract

We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.

DOI10.1093/cercor/bhaa035
Alternate JournalCereb Cortex
PubMed ID32198502
PubMed Central IDPMC7947185
Grant ListR01 AG064955 / AG / NIA NIH HHS / United States
MR/R024065/1 / MRC_ / Medical Research Council / United Kingdom
MR/K026992/1 / MRC_ / Medical Research Council / United Kingdom
MR/N027558/1 / MRC_ / Medical Research Council / United Kingdom
G0701120 / MRC_ / Medical Research Council / United Kingdom
G0700704 / MRC_ / Medical Research Council / United Kingdom
BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
MR/M013111/1 / MRC_ / Medical Research Council / United Kingdom
G1001245 / MRC_ / Medical Research Council / United Kingdom
R01 AG022381 / AG / NIA NIH HHS / United States
R01 AG050595 / AG / NIA NIH HHS / United States