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Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort.

TitleLow Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort.
Publication TypeJournal Article
Year of Publication2020
AuthorsAlam AB, Lutsey PL, Gottesman RF, Tin A, Alonso A
Date Published2020 Oct 09
KeywordsCohort Studies, Dementia, Female, Follow-Up Studies, Humans, Incidence, Magnesium, Magnesium Deficiency, Male, Middle Aged, Risk, Time Factors

Higher serum magnesium is associated with lower risk of multiple morbidities, including diabetes, stroke, and atrial fibrillation, but its potential neuroprotective properties have also been gaining traction in cognitive function and decline research. We studied 12,040 participants presumed free of dementia in the Atherosclerosis Risk in Communities (ARIC) study. Serum magnesium was measured in fasting blood samples collected in 1990-1992. Dementia status was ascertained through cognitive examinations in 2011-2013, 2016-2017, and 2018-2019, along with informant interviews and indicators of dementia-related hospitalization events and death. Participants' cognitive functioning capabilities were assessed up to five times between 1990-1992 and 2018-2019. The cognitive function of participants who did not attend follow-up study visits was imputed to account for attrition. We identified 2519 cases of dementia over a median follow-up period of 24.2 years. The lowest quintile of serum magnesium was associated with a 24% higher rate of incident dementia compared to those in the highest quintile of magnesium (HR, 1.24; 95% CI, 1.07, 1.44). No relationship was found between serum magnesium and cognitive decline in any cognitive domain. Low midlife serum magnesium is associated with increased risk of incident dementia, but does not appear to impact rates of cognitive decline.

Alternate JournalNutrients
PubMed ID33050118
PubMed Central IDPMC7600951
Grant ListK24 HL148521 / HL / NHLBI NIH HHS / United States
P30 AG066511 / AG / NIA NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
U01 2U01HL096812, 2U01HL096814, 2U01HL096899, 2U01HL096902, 2U01HL096917, K24HL148521 / HL / NHLBI NIH HHS / United States