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Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts.

TitlePrevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts.
Publication TypeJournal Article
Year of Publication2021
AuthorsHicks CW, Wang D, B Windham G, Matsushita K, Selvin E
JournalSci Rep
Volume11
Issue1
Pagination19159
Date Published2021 Sep 27
ISSN2045-2322
Abstract

Peripheral neuropathy is associated with substantial morbidity, but risk factors other than diabetes are largely uncharacterized. The aim of this study was to describe the prevalence and risk factors for peripheral neuropathy in adults with and without diabetes from two different population-based studies in the US. We performed a cross-sectional analysis of 5200 black and white participants from NHANES (1999-2004, age 40-85 years) and 3362 black and white participants from the ARIC Study (2016-2017, age 70-89 years) who underwent monofilament testing for peripheral neuropathy using a shared protocol. We used logistic regression to quantify age, sex, and race-adjusted risk factor associations for peripheral neuropathy among middle-aged (40-69 years) and older (≥ 70 years) adults. The age, sex, and race-adjusted prevalence of peripheral neuropathy (decreased sensation on monofilament testing) was 10.4% for middle-aged adults in NHANES, 26.8% for older adults in NHANES, and 39.2% for older adults in ARIC. Diabetes was an important risk factor, but more strongly associated with peripheral neuropathy in middle-aged (OR ~ 5 for long-standing diabetes) compared to older adults (ORs ~ 1.5-2). Male sex (ORs ~ 2), black race (ORs ~ 1.3-1.5), and greater height (ORs ~ 1.5-3) were robust risk factors for peripheral neuropathy. Other risk factors included body mass index, education, and peripheral artery disease. The burden of peripheral neuropathy defined by abnormal monofilament testing among older adults is substantial, even among adults without diabetes. Studies are needed to understand the etiology and prognosis of peripheral neuropathy in the absence of diabetes.

DOI10.1038/s41598-021-98565-w
Alternate JournalSci Rep
PubMed ID34580377
PubMed Central IDPMC8476511
Grant ListK23DK124515 / DK / NIDDK NIH HHS / United States
K24DK106414 / DK / NIDDK NIH HHS / United States
R21HL133694 / HL / NHLBI NIH HHS / United States