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Incidence of diabetes in South Asian young adults compared to Pima Indians.

TitleIncidence of diabetes in South Asian young adults compared to Pima Indians.
Publication TypeJournal Article
Year of Publication2021
AuthorsNarayan KMVenkat, Kondal D, Kobes S, Staimez LR, Mohan D, Gujral UP, Patel SA, Anjana RMohan, Shivashankar R, Ali MK, Chang HH, Kadir M, Prabhakaran D, Daya N, Selvin E, Tandon N, Hanson R, Mohan V
JournalBMJ Open Diabetes Res Care
Volume9
Issue1
Date Published2021 03
ISSN2052-4897
KeywordsAdult, Asian Continental Ancestry Group, Diabetes Mellitus, Female, Humans, Incidence, India, Indians, North American, Insulin, Male, Potassium Iodide, Prospective Studies, Young Adult
Abstract

INTRODUCTION: South Asians (SA) and Pima Indians have high prevalence of diabetes but differ markedly in body size. We hypothesize that young SA will have higher diabetes incidence than Pima Indians at comparable body mass index (BMI) levels.

RESEARCH DESIGN AND METHODS: We used prospective cohort data to estimate age-specific, sex, and BMI-specific diabetes incidence in SA aged 20-44 years living in India and Pakistan from the Center for Cardiometabolic Risk Reduction in South Asia Study (n=6676), and compared with Pima Indians, from Pima Indian Study (n=1852).

RESULTS: At baseline, SA were considerably less obese than Pima Indians (BMI (kg/m): 24.4 vs 33.8; waist circumference (cm): 82.5 vs 107.0). Age-standardized diabetes incidence (cases/1000 person-years, 95% CI) was lower in SA than in Pima Indians (men: 14.2, 12.2-16.2 vs 37.3, 31.8-42.8; women: 14.8, 13.0-16.5 vs 46.1, 41.2-51.1). Risk of incident diabetes among 20-24-year-old Pima men and women was six times (relative risk (RR), 95% CI: 6.04, 3.30 to 12.0) and seven times (RR, 95% CI: 7.64, 3.73 to 18.2) higher as compared with SA men and women, respectively. In those with BMI

DOI10.1136/bmjdrc-2020-001988
Alternate JournalBMJ Open Diabetes Res Care
PubMed ID33771765
PubMed Central IDPMC8006824
Grant ListKL2 TR002381 / TR / NCATS NIH HHS / United States
UL1 TR002378 / TR / NCATS NIH HHS / United States
HHSN268200900026C / HL / NHLBI NIH HHS / United States
P30 DK111024 / DK / NIDDK NIH HHS / United States
R01 HL125442 / HL / NHLBI NIH HHS / United States
WT084754/Z/08/A / WT_ / Wellcome Trust / United Kingdom
D43 TW009135 / TW / FIC NIH HHS / United States