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Cognition and 20-year subsequent sleep disturbances.

TitleCognition and 20-year subsequent sleep disturbances.
Publication TypeJournal Article
Year of Publication2021
AuthorsWest NA, Johnson DA, Lutsey PL, Mosley TH, Redline S
JournalSleep Health
Date Published2021 Mar 06
ISSN2352-7226
Abstract

INTRODUCTION: There is a paucity of data exploring the extent that preclinical cognitive changes are predictive of subsequent sleep outcomes.

METHODS: Logistic regression models were used to evaluate data from a cohort of 196 African American adults who had measures of cognitive function assessed at 2 time points during a 20-year period across the mid- to late-life transition. Cognitive testing included the Delayed Word Recall, the Digit Symbol Substitution, and the Word Fluency tests, which were summarized as a composite cognitive z-score. Sleep apnea was measured by in-home sleep apnea testing and sleep duration and quality were derived from 7-day wrist actigraphy at the end of the study period.

RESULTS: A one standard deviation (SD) lower composite cognitive z-score at baseline was significantly associated with greater odds of low sleep efficiency (60 minutes) (OR = 1.65, 95% CI = 1.05, 2.60) in adjusted models. A one SD faster rate of cognitive decline over the study period was significantly associated with greater odds of low sleep efficiency (OR = 1.68, 95% CI = 1.04, 2.73), greater odds of sleep fragmentation (>35%); (OR = 1.73, 95% CI = 1.05, 2.85), and greater odds of increased WASO (OR = 1.85, 95% CI = 1.15, 2.95) in adjusted models. Neither baseline cognitive z-score nor rate of cognitive decline was associated with sleep apnea or the total average sleep duration.

CONCLUSION: Cognition at baseline and change over time predicts sleep quality and may reflect common neural mechanisms and vulnerabilities.

DOI10.1016/j.sleh.2021.01.008
Alternate JournalSleep Health
PubMed ID33750660
Grant ListK01 HL138211 / HL / NHLBI NIH HHS / United States