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Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease.

TitleMetabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease.
Publication TypeJournal Article
Year of Publication2021
AuthorsHe WJ, Chen J, Razavi AC, Hu EA, Grams ME, Yu B, Parikh CR, Boerwinkle E, Bazzano L, Qi L, Kelly TN, Coresh J, Rebholz CM
JournalClin J Am Soc Nephrol
Volume16
Issue11
Pagination1620-1629
Date Published2021 11
ISSN1555-905X
Abstract

BACKGROUND AND OBJECTIVES: Moderate coffee consumption has been associated with lower risk of CKD; however, the exact biologic mechanisms underlying this association are unknown. Metabolomic profiling may identify metabolic pathways that explain the association between coffee and CKD. The goal of this study was to identify serum metabolites associated with coffee consumption and examine the association between these coffee-associated metabolites and incident CKD.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using multivariable linear regression, we identified coffee-associated metabolites among 372 serum metabolites available in two subsamples of the Atherosclerosis Risk in Communities study (ARIC; =3811). Fixed effects meta-analysis was used to pool the results from the two ARIC study subsamples. Associations between coffee and metabolites were replicated in the Bogalusa Heart Study (=1043). Metabolites with significant associations with coffee in both cohorts were then evaluated for their prospective associations with incident CKD in the ARIC study using Cox proportional hazards regression.

RESULTS: In the ARIC study, mean (SD) age was 54 (6) years, 56% were daily coffee drinkers, and 32% drank >2 cups per day. In the Bogalusa Heart Study, mean (SD) age was 48 (5) years, 57% were daily coffee drinkers, and 38% drank >2 cups per day. In a meta-analysis of two subsamples of the ARIC study, 41 metabolites were associated with coffee consumption, of which 20 metabolites replicated in the Bogalusa Heart Study. Three of these 20 coffee-associated metabolites were associated with incident CKD in the ARIC study.

CONCLUSIONS: We detected 20 unique serum metabolites associated with coffee consumption in both the ARIC study and the Bogalusa Heart Study, and three of these 20 candidate biomarkers of coffee consumption were associated with incident CKD. One metabolite (glycochenodeoxycholate), a lipid involved in primary bile acid metabolism, may contribute to the favorable kidney health outcomes associated with coffee consumption. Two metabolites (-methylcatechol sulfate and 3-methyl catechol sulfate), both of which are xenobiotics involved in benzoate metabolism, may represent potential harmful aspects of coffee on kidney health.

DOI10.2215/CJN.05520421
Alternate JournalClin J Am Soc Nephrol
PubMed ID34737201
PubMed Central IDPMC8729408
Grant ListUH3 DK114866 / DK / NIDDK NIH HHS / United States
R01 DK093770 / DK / NIDDK NIH HHS / United States
R56 HL153178 / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
R21 HL143089 / HL / NHLBI NIH HHS / United States
P20 GM109036 / GM / NIGMS NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
R01 AG041200 / AG / NIA NIH HHS / United States
R21 AG051914 / AG / NIA NIH HHS / United States
R03 DK128386 / DK / NIDDK NIH HHS / United States
F30 HL147486 / HL / NHLBI NIH HHS / United States
U01 HG004402 / HG / NHGRI NIH HHS / United States
K01 DK107782 / DK / NIDDK NIH HHS / United States
P30 ES030285 / ES / NIEHS NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
R01 HL085757 / HL / NHLBI NIH HHS / United States
HHSN268201700003C / HL / NHLBI NIH HHS / United States
U01 DK106962 / DK / NIDDK NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States