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Associations Between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study.

TitleAssociations Between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study.
Publication TypeJournal Article
Year of Publication2022
AuthorsJohansen MC, Wang W, Zhang MJ, Alonso A, Wong DF, Gottesman RF, Chen LY
JournalJ Alzheimers Dis
Volume86
Issue1
Pagination43-48
Date Published2022
ISSN1875-8908
KeywordsAged, Amyloid beta-Peptides, Aniline Compounds, Atrial Fibrillation, Brain, Cognition, Humans, Positron-Emission Tomography
Abstract

The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (> 1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

DOI10.3233/JAD-215378
Alternate JournalJ Alzheimers Dis
PubMed ID35001894
PubMed Central IDPMC8996481
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
P30 AG066511 / AG / NIA NIH HHS / United States
R01 AG040282 / AG / NIA NIH HHS / United States
HHSN268201700002C / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
K23 NS112459 / NS / NINDS NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
R01 HL126637 / HL / NHLBI NIH HHS / United States
K24 HL155813 / HL / NHLBI NIH HHS / United States
16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States
K24 HL148521 / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700005C / HL / NHLBI NIH HHS / United States
HHSN268201700001C / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States
R01 HL141288 / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States