Title | 6-year change in high sensitivity cardiac troponin T and the risk of atrial fibrillation in the Atherosclerosis Risk in Communities cohort. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Li L, Selvin E, Hoogeveen RC, Soliman EZ, Chen LY, Norby FL, Alonso A |
Journal | Clin Cardiol |
Volume | 44 |
Issue | 11 |
Pagination | 1594-1601 |
Date Published | 2021 Nov |
ISSN | 1932-8737 |
Keywords | Atherosclerosis, Atrial Fibrillation, Biomarkers, Humans, Prospective Studies, Risk Factors, Troponin T |
Abstract | BACKGROUND: Circulating high sensitivity cardiac troponin T (hs-cTnT) is associated with incidence of atrial fibrillation (AF), but the association of changes in hs-cTnT over time on incident AF has not been explored. HYPOTHESIS: Six-year increase in circulating hs-cTnT will be associated with increased risk of AF and will contribute to improved prediction of incident AF. METHODS: We conducted a prospective cohort analysis of 8431 participants from the Atherosclerosis Risk in Communities (ARIC) study. hs-cTnT change was categorized at visit 2 and 4 as undetectable ( RESULTS: Over a mean follow-up of 16.5 years, 1629 incident AF cases were diagnosed. Among participants with undetectable hs-cTnT at visit 2, the multivariable HR of AF was 1.28 (95% CI 1.12-1.48) among those with detectable or elevated hs-cTnT at visit 4 compared to those in which hs-cTnT remained undetectable. Among those with detectable hs-cTnT at visit 2, compared to those who remained in the detectable hs-cTnT group, reduction to undetectable at visit 4 was associated with lower risk of AF (HR 0.74, 95% CI 0.59-0.94), while increment to elevated was associated with higher AF risk (HR 1.30, 95% CI 1.01-1.68). Adding hs-cTnT change to our main model with baseline hs-cTnT did not result in significant improvement in the C-statistic or substantial NRI. CONCLUSION: Six-year increase in circulating hs-cTnT was associated with elevated risk of incident AF. |
DOI | 10.1002/clc.23727 |
Alternate Journal | Clin Cardiol |
PubMed ID | 34545585 |
PubMed Central ID | PMC8571551 |
Grant List | K24 HL152440 / HL / NHLBI NIH HHS / United States K24HL148521 / HL / NHLBI NIH HHS / United States 16EIA26410001 / AHA / American Heart Association-American Stroke Association / United States HHSN268201700002C / HL / NHLBI NIH HHS / United States HHSN268201700001I / HL / NHLBI NIH HHS / United States HHSN268201700004C / HL / NHLBI NIH HHS / United States R01 HL134320 / HL / NHLBI NIH HHS / United States HHSN268201700003I / HL / NHLBI NIH HHS / United States 16EIA26410001 / / American Heart Association / R01 DK089174 / DK / NIDDK NIH HHS / United States K24 HL148521 / HL / NHLBI NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States HHSN268201700004I / HL / NHLBI NIH HHS / United States HHSN268201700005C / HL / NHLBI NIH HHS / United States HHSN268201700001C / HL / NHLBI NIH HHS / United States HHSN268201700003C / HL / NHLBI NIH HHS / United States HHSN268201700002I / HL / NHLBI NIH HHS / United States HHSN268201700005I / HL / NHLBI NIH HHS / United States |