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Obesity, Galectin-3, and Incident Heart Failure: The ARIC Study.

TitleObesity, Galectin-3, and Incident Heart Failure: The ARIC Study.
Publication TypeJournal Article
Year of Publication2022
AuthorsFlorido R, Kwak L, Echouffo-Tcheugui JB, Zhang S, Michos ED, Nambi V, Goldberg RB, Hoogeveen RC, Lazo M, Gerstenblith G, Post WS, Blumenthal RS, Coresh J, Folsom AR, Selvin E, Ballantyne C, Ndumele CE
JournalJ Am Heart Assoc
Volume11
Issue9
Paginatione023238
Date Published2022 05 03
ISSN2047-9980
KeywordsBlood Proteins, Female, Fibrosis, Galectin 3, Galectins, Heart Failure, Humans, Inflammation, Male, Middle Aged, Obesity, Obesity, Morbid
Abstract

Background Laboratory data suggest obesity is linked to myocardial inflammation and fibrosis, but clinical data are limited. We aimed to examine the association of obesity with galectin-3, a biomarker of cardiac inflammation and fibrosis, and the related implications for heart failure (HF) risk. Methods and Results We evaluated 8687 participants (mean age 63 years; 21% Black) at ARIC (Atherosclerosis Risk in Communities) Visit 4 (1996-1998) who were free of heart disease. We used adjusted logistic regression to estimate the association of body mass index (BMI) categories with elevated galectin-3 (≥75th sex-specific percentile) overall and across demographic subgroups, with tests for interaction. We used Cox proportional hazards models to assess the combined associations of galectin-3 and BMI with incident HF (through December 31, 2019). Higher BMI was associated with higher odds of elevated galectin-3 (odds ratio [OR], 2.32; 95% CI, 1.88-2.86) for severe obesity ([BMI ≥35 kg/m] versus normal weight [BMI 18.5-4-fold higher risk of HF (HR, 4.19; 95% CI, 2.98-5.88) than those with normal weight and galectin-3

DOI10.1161/JAHA.121.023238
Alternate JournalJ Am Heart Assoc
PubMed ID35491999
PubMed Central IDPMC9238585
Grant ListK24 HL152440 / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States
R01 HL146907 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
K23 HL153774 / HL / NHLBI NIH HHS / United States