Pulse lineResearch With Heart Logo

The prospective association between periodontal disease and brain imaging outcomes: The Atherosclerosis Risk in Communities study.

TitleThe prospective association between periodontal disease and brain imaging outcomes: The Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2022
AuthorsAdam HS, Lakshminarayan K, Wang W, Norby FL, Mosley T, Walker KA, Gottesman RF, Meyer K, Hughes TM, Pankow JS, Wong DF, Jack CR, Sen S, Lutsey PL, Beck J, Demmer RT
JournalJ Clin Periodontol
Volume49
Issue4
Pagination322-334
Date Published2022 04
ISSN1600-051X
KeywordsAged, Amyloid beta-Peptides, Atherosclerosis, Brain, Humans, Neuroimaging, Periodontal Diseases, Tooth Loss
Abstract

AIM: We investigate if periodontal disease is prospectively associated with cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology.

MATERIALS AND METHODS: N = 1306 participants (Visit 5 mean age = 76.5 [standard deviation = 5.4] years) in the Atherosclerosis Risk in Communities study with completed dental exams at Visit 4 underwent brain magnetic resonance imaging scans at Visit 5 while N = 248 underwent positron emission tomography scans. Participants were classified as edentulous or, among the dentate, by the modified Periodontal Profile Class. Brain volumes were regressed on periodontal status in linear regressions. Cerebrovascular measures and β-amyloid positivity were regressed on periodontal status in logistic regressions.

RESULTS: Periodontal disease was not associated with brain volumes, microhaemorrhages, or elevated β-amyloid. Compared with periodontally healthy individuals, odds ratios [95% confidence interval] for all-type infarcts were 0.37 [0.20, 0.65] for severe tooth loss and 0.56 [0.31, 0.99] for edentulous participants.

CONCLUSIONS: Within the limitations of this study, periodontal disease was not associated with altered brain volumes, microhaemorrhages, or β-amyloid positivity. Tooth loss was associated with lower odds of cerebral infarcts.

DOI10.1111/jcpe.13586
Alternate JournalJ Clin Periodontol
PubMed ID34905804
PubMed Central IDPMC8934294
Grant List2U01HL096899 / HL / NHLBI NIH HHS / United States
2U01HL096814 / HL / NHLBI NIH HHS / United States
2U01HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
R01 AG040282 / AG / NIA NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
UL1 TR001111 / TR / NCATS NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
R01-HL70825 / HB / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U012U01HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
UL1-TR001111 / NH / NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
R01-DE021418 / DE / NIDCR NIH HHS / United States
2U01HL096902 / HL / NHLBI NIH HHS / United States
R01AG040282 / AG / NIA NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
R01-DE021986 / DE / NIDCR NIH HHS / United States
5T32 HL 7779-27 / NH / NIH HHS / United States
CON000000080742 / HL / NHLBI NIH HHS / United States
R01 DE021418 / DE / NIDCR NIH HHS / United States