Pulse lineResearch With Heart Logo

Associations of Visual Function With Cognitive Performance in Community-Based Older Adults: The Eye Determinants of Cognition Study.

TitleAssociations of Visual Function With Cognitive Performance in Community-Based Older Adults: The Eye Determinants of Cognition Study.
Publication TypeJournal Article
Year of Publication2021
AuthorsArsiwala LT, Guo X, Ramulu PY, A Sharrett R, Mihailovic A, Swenor BK, Mosley T, Dong Y, Abraham AG
JournalJ Gerontol A Biol Sci Med Sci
Date Published2021 Nov 20
ISSN1758-535X
Abstract

BACKGROUND: Given the detrimental impacts of visual and cognitive impairment separately, in older adults, understanding their coexistence could inform strategies against age-related cognitive changes.

METHODS: Participants from Washington County (White) and Jackson (Black) sites of the Atherosclerosis Risk in Communities Study were recruited who differed on racial, regional, urbanicity, and community-based factors. Presenting distance visual acuity (DVA; representing vision loss due to disease or lack of eye-care), corrected DVA (representing optimal correction for refractive loss of vision), and contrast sensitivity were measured. Factor scores for global cognition, memory, executive function, and language domains were calculated for 3 visits. We quantified the associations of vision measures with change in cognitive scores, stratified by community/race, using generalized estimating equations.

RESULTS: In 982 participants, mean (standard deviation [SD]) baseline age was 74 (4) years, with 37% males and 45% Jackson/Black participants. As hypothesized, after accounting for potential confounders, in the better-eye, worse presenting DVA was associated with greater 10-year decline rate in global cognition, memory, and executive function in Washington County/White participants (eg, global cognition: -0.08 SD [95% confidence interval: -0.12, -0.04]). Worse corrected DVA was associated with greater 10-year decline rate in executive function in Washington County/White participants (-0.10 SD [-0.15, -0.04]). Better contrast sensitivity was associated with lower 10-year decline rate in global cognition and executive function in Washington County/White participants (eg, global cognition: 0.10 SD [0.06,0.14]). None of these associations were confirmed in Jackson/Black participants.

CONCLUSIONS: Our study supports a functional link between some vision measures and cognition in older adults, but in only 1 of the 2 communities studied.

DOI10.1093/gerona/glab349
Alternate JournalJ Gerontol A Biol Sci Med Sci
PubMed ID35089306
Grant List1R01AG052412 / AG / NIA NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
/ NH / NIH HHS / United States
/ NS / NINDS NIH HHS / United States
U01 2U01HL096812 / DC / NIDCD NIH HHS / United States