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Relationship Between Age at Menopause, Obesity, and Incident Heart Failure: The Atherosclerosis Risk in Communities Study.

TitleRelationship Between Age at Menopause, Obesity, and Incident Heart Failure: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2022
AuthorsEbong IA, Wilson MD, Appiah D, Michos ED, Racette SB, Villablanca A, Breathett K, Lutsey PL, Wellons M, Watson KE, Chang P, Bertoni AG
JournalJ Am Heart Assoc
Volume11
Issue8
Paginatione024461
Date Published2022 04 19
ISSN2047-9980
KeywordsAtherosclerosis, Body Mass Index, Female, Heart Failure, Humans, Incidence, Male, Menopause, Middle Aged, Obesity, Risk Factors
Abstract

Background The mechanisms linking menopausal age and heart failure (HF) incidence are controversial. We investigated for heterogeneity by obesity on the relationship between menopausal age and HF incidence. Methods and Results Using postmenopausal women who attended the Atherosclerosis Risk in Communities Study Visit 4, we estimated hazard ratios of incident HF associated with menopausal age using Cox proportional hazards models, testing for effect modification by obesity and adjusting for HF risk factors. Women were categorized by menopausal age:

DOI10.1161/JAHA.121.024461
Alternate JournalJ Am Heart Assoc
PubMed ID35416049
PubMed Central IDPMC9238466
Grant ListK01 HL142848 / HL / NHLBI NIH HHS / United States
HHSN268201700001I / HL / NHLBI NIH HHS / United States
L30 HL148881 / HL / NHLBI NIH HHS / United States
UL1 TR001860 / TR / NCATS NIH HHS / United States
HHSN268201700002I / HL / NHLBI NIH HHS / United States
HHSN268201700004I / HL / NHLBI NIH HHS / United States
R25 HL126146 / HL / NHLBI NIH HHS / United States
HHSN268201700005I / HL / NHLBI NIH HHS / United States
R56 HL159216 / HL / NHLBI NIH HHS / United States
HHSN268201700003I / HL / NHLBI NIH HHS / United States
R25 HL105400 / HL / NHLBI NIH HHS / United States
HHSN268201700004C / HL / NHLBI NIH HHS / United States