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Association of Pulmonary Function With Late-Life Cardiac Function and Heart Failure Risk: The ARIC Study.

TitleAssociation of Pulmonary Function With Late-Life Cardiac Function and Heart Failure Risk: The ARIC Study.
Publication TypeJournal Article
Year of Publication2022
AuthorsRamalho SHR, Claggett BL, Washko GR, Estepar RSan Jose, Chang PP, Kitzman DW, Junior GCipriano, Solomon SD, Skali H, Shah AM
JournalJ Am Heart Assoc
Volume11
Issue14
Paginatione023990
Date Published2022 Jul 19
ISSN2047-9980
KeywordsAged, Aged, 80 and over, Cohort Studies, Female, Heart Failure, Humans, Lung, Male, Stroke Volume, Ventricular Function, Left, Vital Capacity
Abstract

Background Pulmonary and cardiac functions decline with age, but the associations of pulmonary dysfunction with cardiac function and heart failure (HF) risk in late life is not known. We aimed to determine the associations of percent predicted forced vital capacity (ppFVC) and the ratio of forced expired volume in 1 second (FEV) to forced vital capacity (FVC; FEV/FVC) with cardiac function and incident HF with preserved or reduced ejection fraction in late life. Methods and Results Among 3854 HF-free participants in the ARIC (Atherosclerosis Risk in Communities) cohort study who underwent echocardiography and spirometry at the fifth study visit (2011-2013), associations of FEV/FVC and ppFVC with echocardiographic measures, cardiac biomarkers, and risk of HF, HF with preserved ejection fraction, and HF with reduced ejection fraction were assessed. Multivariable linear and Cox regression models adjusted for demographics, body mass index, coronary disease, atrial fibrillation, hypertension, and diabetes. Mean age was 75±5 years, 40% were men, 19% were Black, and 61% were ever smokers. Mean FEV/FVC was 72±8%, and ppFVC was 98±17%. In adjusted analyses, lower FEV/FVC and ppFVC were associated with higher NT-proBNP (N-terminal pro-B-type natriuretic peptide; both

DOI10.1161/JAHA.121.023990
Alternate JournalJ Am Heart Assoc
PubMed ID35861819