Pulse lineResearch With Heart Logo

Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.

TitlePulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.
Publication TypeJournal Article
Year of Publication2022
AuthorsLee M, Huan T, McCartney DL, Chittoor G, de Vries M, Lahousse L, Nguyen JN, Brody JA, Castillo-Fernandez J, Terzikhan N, Qi C, Joehanes R, Min JL, Smilnak GJ, Shaw JR, Yang CXi, Colicino E, Hoang TT, Bermingham ML, Xu H, Justice AE, Xu C-J, Rich SS, Cox SR, Vonk JM, Prokić I, Sotoodehnia N, Tsai P-C, Schwartz JD, Leung JM, Sikdar S, Walker RM, Harris SE, van der Plaat DA, Van Den Berg DJ, Bartz TM, Spector TD, Vokonas PS, Marioni RE, Taylor AM, Liu Y, Barr GR, Lange LA, Baccarelli AA, Obeidat M'en, Fornage M, Wang T, Ward JM, Motsinger-Reif AA, Hemani G, Koppelman GH, Bell JT, Gharib SA, Brusselle G, H Boezen M, North KE, Levy D, Evans KL, Dupuis J, Breeze CE, Manichaikul A, London SJ
JournalAm J Respir Crit Care Med
Volume206
Issue3
Pagination321-336
Date Published2022 08 01
ISSN1535-4970
KeywordsCpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenome, Epigenomics, Genome-Wide Association Study, Humans, Infant, Newborn, Lung
Abstract

Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV, FVC, and FEV/FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate,

DOI10.1164/rccm.202108-1907OC
Alternate JournalAm J Respir Crit Care Med
PubMed ID35536696
Grant ListR01 HL105756 / HL / NHLBI NIH HHS / United States
HL105756 / HL / NHLBI NIH HHS / United States
Z01-ES043012 / ES / NIEHS NIH HHS / United States